Poster (Scientific congresses and symposiums)
One-pot water-compatible synthesis of [PdX(PPh3)2Ar] complexes and evaluation of their radical scavenging activity in ABTS, DPPH and HRP-H2O2/L012 models
Etse, Koffi Senam; Mouithys-Mickalad, Ange; Demonceau, Albert
2016GECOM-CONCOORD 2016
 

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Keywords :
Organopalladium; one-pot water-compatible synthesis; radical scavenging activity
Abstract :
[en] Organopalladium complexes with the general formula [PdX(PPh3)2Ar] are well-known and widely used as efficient catalysts for numerous organic reactions. Nowadays, palladium complexes are also studied for their biological activities.[1] In this contribution, we present a novel one-pot water-compatible synthesis of trans square-planar [PdX(PPh3)2Ar] complexes and their radical scavenging activity. [PdI(PPh3)2(4-RC6H4)] with R = H, MeO, AcO, were readily obtained by oxidative addition of p-RC6H4I on Pd(PPh3)4. By contrast, bromo- and chloropalladium analogues were synthesized by a novel one-pot procedure by reacting overnight Pd(PPh3)4, p-RC6H4I and KBr or KCl in toluene/water suspension. This method avoids degradation of the complexes during decantation under air and the use of toxic benzyltriethylammonium bromide or chloride.[2] Investigation of the antioxidant properties showed that these complexes exhibit a strong radical scavenging activity against DPPH (1,1-diphenyl-2-picrylhydrazyl) radical, in a dose-dependent manner. Complexes [PdI(PPh3)2(4-MeOC6H4)] and [PdCl(PPh3)2(4-MeOC6H4)] showed the highest activity with IC50 equal to 1.14 and 1.9 μM, respectively. These results were confirmed in ABTS (2, 2-azinobis(3-ethyl-benzothiazoline-6-sulfonic acid)) radical scavenging tests, and compared favorably with those obtained with cis-platine and quercetine. The enzymatic model used to evaluate their antiradical scavenging activity was based on their interaction with the HRP (horseradish peroxidase) -H2O2/L012 (8-amino-5-chloro-7-phenylpyrido[2,4-d]pyridazine-1,4(2H,3H)dione) system.
Research center :
Laboratoire de Catalyse
CORD - Centre de l'Oxygène, Recherche et Développement - ULiège
Disciplines :
Chemistry
Author, co-author :
Etse, Koffi Senam ;  Université de Liège - ULiège > Département de chimie (sciences) > Chimie macromoléculaire et catalyse organique
Mouithys-Mickalad, Ange ;  Université de Liège - ULiège > Centre de l'oxygène : Recherche et développement (C.O.R.D.)
Demonceau, Albert ;  Université de Liège - ULiège > Département de chimie (sciences) > Chimie macromoléculaire et catalyse organique
Language :
English
Title :
One-pot water-compatible synthesis of [PdX(PPh3)2Ar] complexes and evaluation of their radical scavenging activity in ABTS, DPPH and HRP-H2O2/L012 models
Publication date :
18 May 2016
Number of pages :
A0
Event name :
GECOM-CONCOORD 2016
Event organizer :
Université de Strasbourg
Event place :
Obernai, France
Event date :
du 16 au 20 mai 2016
Audience :
International
Available on ORBi :
since 17 January 2020

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