Reference : Impairment of neuromuscular transmission in a subgroup of migraine patients
Scientific journals : Article
Social & behavioral sciences, psychology : Neurosciences & behavior
Human health sciences : Neurology
http://hdl.handle.net/2268/24215
Impairment of neuromuscular transmission in a subgroup of migraine patients
English
Ambrosini, Anna [> > > >]
MAERTENS DE NOORDHOUT, Alain mailto [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie CHR >]
Alagona, Giovanna [> > > >]
Dalpozzo, Francesca [> > > >]
SCHOENEN, Jean mailto [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie CHR]
1999
Neuroscience Letters
Elsevier
276
3
201-3
Yes (verified by ORBi)
International
0304-3940
1872-7972
Limerick
Ireland
[en] Adult ; Electromyography ; Female ; Humans ; Male ; Middle Aged ; Migraine with Aura/physiopathology ; Neuromuscular Junction/physiopathology ; Single-Blind Method ; Synaptic Transmission
[en] Neuronal voltage-dependent P/Q Ca2+ channels are genetically abnormal in many cases of familial hemiplegic migraine and possibly associated with the more common forms of migraine with and without aura. Besides the brain, these channels are found in motor nerve endings where they control stimulation-induced acetylcholine release. Using single fiber EMG recordings we were able to demonstrate subclinical abnormalities of neuromuscular transmission in a subgroup of patients suffering from migraine with aura. This could be related to genetic abnormalities of P/Q Ca2+ channels in certain patients suffering from migraine with aura, which needs to be explored by proper genetic analyses.
http://hdl.handle.net/2268/24215
also: http://hdl.handle.net/2268/106749
10.1016/S0304-3940(99)00820-4

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