Salivary excretion of rabies virus by healthy vampire bats

Animals; Chiroptera/virology; DNA, Viral/analysis; Female; Male; Polymerase Chain Reaction; Rabies/veterinary/virology; Rabies virus/pathogenicity; Saliva/virology

Abstract :

[en] Salivary excretion of rabies virus was evaluated in 14 adult vampire bats (Desmodus rotundus) intramuscularly injected with a large dose (10(6) MICLD50) of vampire rabies virus variant CASS88. Saliva samples were obtained from surviving bats every other day for 30 days, then weekly for 2 months, and finally 1 and 2 years later. Rabies virus was isolated in murine neuroblastoma cells and in randomly selected cases by PCR. Rabies virus was not detected in the saliva of any of the 11 animals that succumbed (somewhat early) to rabies challenge, nor in the control bats. In contrast, virus was detected early, and only once (days 6, 6 and 21) in each of the three animals that survived rabies challenge and remained healthy for at least 2 years after challenge. At that time even vigorous dexamethasone and cyclosporine administration failed to provoke further viral excretion.

Disciplines :

Veterinary medicine & animal health

Author, co-author :

Aguilar-Setien, A.; Hospital de Pediatria, Centro Medico Nacional Siglo XXI > Unidad de Investigacion Medica en Inmunologıa

Loza-Rubio, E.; Instituto Nacional de Investigaciones Forestales y Agropecuarias > Centro Nacional de Investigaciones Disciplinarias en Microbiologıa

Salas-Rojas, M.; Hospital de Pediatria, Centro Medico Nacional Siglo XXI > Unidad de Investigacion Medica en Inmunologıa

Brisseau, N.; Laboratoire d ’études et de recherches sur la rage et la pathologie des animaux sauvages

Cliquet, F.; Laboratoire d ’études et de recherches sur la rage et la pathologie des animaux sauvages

Pastoret, Paul-Pierre ; Institute for Animal Health

Rojas-Dotor, S.; Hospital de Pediatria, Centro Medico Nacional Siglo XXI > Unidad de Investigacion Medica en Inmunologıa

Tesoro, E.; Instituto Nacional de Ciencias Medicas y Nutricion > Departamento de Investigacion Experimental y Bioterio

Kretschmer, R.; Hospital de Pediatria, Centro Medico Nacional Siglo XXI > Unidad de Investigacion Medica en Inmunologıa

Language :

English

Title :

Salivary excretion of rabies virus by healthy vampire bats

Publication date :

2005

Journal title :

Epidemiology and Infection

ISSN :

0950-2688

eISSN :

1469-4409

Publisher :

Cambridge University Press, Cambridge, United Kingdom

Volume :

133

Issue :

Pages :

517-22

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 06 December 2019

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