Article (Scientific journals)
Neuromuscular transmission in migraine patients with prolonged aura
Ambrosini, Anna; MAERTENS DE NOORDHOUT, Alain; SCHOENEN, Jean
2001In Acta Neurologica Belgica, 101 (3), p. 166-70
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Keywords :
Action Potentials/genetics; Adult; Calcium Channels, P-Type/genetics/metabolism; Calcium Channels, Q-Type/genetics/metabolism; Electric Stimulation; Female; Humans; Male; Migraine with Aura/complications/genetics/physiopathology; Neural Conduction/genetics; Neuromuscular Junction/metabolism/physiopathology; Peripheral Nerves/physiopathology; Reaction Time/genetics; Synaptic Transmission/genetics
Abstract :
[en] P/Q Ca2+ channels are genetically abnormal in most cases of familial hemiplegic migraine (FHM) and may be involved in other types of migraine. They are also found at the neuromuscular junctions, where they control stimulation-induced acetylcholine release. Prolonged aura is a very frequent clinical feature in FHM patients. The objective of this study was thus to explore neuromuscular transmission in migraine with typical and prolonged aura patients. We performed single fiber electromyography (SFEMG) in such patients and compared them to a group of healthy volunteers. Results were expressed as mean jitter (MCD) and percentage of single endplate abnormalities. Mean MCD was on average comparable in controls and migraineurs. By contrast, single endplate abnormalities were only found in patients (p < 0.01), especially in those with prolonged aura (p < 0.001). These results suggest subtle impairment of neuromuscular transmission in a subgroup of migraineurs characterized by prolonged aura, which might be due to dysfunctioning P/Q Ca(2+)-channels.
Disciplines :
Neurosciences & behavior
Neurology
Author, co-author :
Ambrosini, Anna
MAERTENS DE NOORDHOUT, Alain  ;  Centre Hospitalier Universitaire de Liège - CHU > Neurologie CHR
SCHOENEN, Jean  ;  Centre Hospitalier Universitaire de Liège - CHU > Neurologie CHR
Language :
English
Title :
Neuromuscular transmission in migraine patients with prolonged aura
Publication date :
2001
Journal title :
Acta Neurologica Belgica
ISSN :
0300-9009
eISSN :
2240-2993
Publisher :
Acta Medica Belgica, Bruxelles, Belgium
Volume :
101
Issue :
3
Pages :
166-70
Peer reviewed :
Peer Reviewed verified by ORBi
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