Reference : Acetazolamide acts on neuromuscular transmission abnormalities found in some migraineurs.
Scientific journals : Article
Human health sciences : Neurology
Social & behavioral sciences, psychology : Neurosciences & behavior
Acetazolamide acts on neuromuscular transmission abnormalities found in some migraineurs.
Ambrosini, A. [> > > >]
Pierelli, F. [> > > >]
Schoenen, Jean mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Neuro-anatomie >]
Blackwell Science
Yes (verified by ORBi)
Osney Mead Oxford
United Kingdom
[en] Acetazolamide/administration & dosage ; Adult ; Calcium Channels, N-Type ; Electromyography/methods ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Migraine with Aura/complications/diagnosis/drug therapy/physiopathology ; Neuromuscular Junction/drug effects/physiopathology ; Neuromuscular Junction Diseases/complications/diagnosis/drug therapy/physiopathology ; Synapses/drug effects ; Treatment Outcome
[en] Mild subclinical impairment of neuromuscular transmission can be detected with single-fibre electromyography (SFEMG) in subgroups of patients suffering from migraine and could be due to dysfunctioning Ca2+-channels on motor axons controlling stimulation-induced acetylcholine release. Acetazolamide, which is thought to ameliorate ion channel function, was shown effective in familial hemiplegic migraine and episodic ataxia type 2, both of which are associated with mutations of the neuronal Ca2+-channel gene CACNA1A, as well as in aura status. We treated therefore in an open pilot study five non-hemiplegic migraineurs showing mild SFEMG abnormalities with acetazolamide for several weeks. This was followed by a normalization of SFEMG recordings in all patients and by clinical improvement in four. These results support the assumption that the subclinical impairment of neuromuscular transmission found in certain migraineurs might be due to dysfunctioning Ca2+-channels.

File(s) associated to this reference

Fulltext file(s):

Restricted access
Acetazolamide acts Ambrosini et al 03.pdfPublisher postprint106.93 kBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.