Electrophysiological studies in migraine: a comprehensive review of their interest and limitations

[en] Electrophysiological methods may help to unravel some of the pathophysiological mechanisms of migraine. Lack of habituation is the principal and most reproducible interictal abnormality in sensory processing in migraineurs. It is found in evoked potential (EP) studies for every stimulation modality including nociceptive stimuli, and it is likely to be responsible for the increased intensity dependence of EP. We have hypothesized that deficient EP habituation in migraine could be due to a reduced preactivation level of sensory cortices because of hypofunctioning subcortico-cortical aminergic pathways. This is not in keeping with simple hyperexcitability of the cortex, which has been suggested by some, but not all, studies of transcranial magnetic stimulation (TMS). A recent study of the effects of repetitive TMS on visual EP strongly supports the hypothesis that migraine is characterized by interictal cortical hypoexcitability. With regard to pain mechanisms in migraine, electrophysiological studies of trigeminal pathways using nociceptive blink and corneal reflexes have confirmed that sensitization of central trigeminal nociceptors occurs during migraine attacks.

Disciplines :

Neurology
Neurosciences & behavior

Author, co-author :

Ambrosini, Anna

Maertens De Noordhout, Alain ; Université de Liège - ULiège > Neurologie CHR

Sandor, P.

Schoenen, Jean ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Neuro-anatomie

Language :

English

Title :

Electrophysiological studies in migraine: a comprehensive review of their interest and limitations

Publication date :

2003

Journal title :

Cephalalgia

ISSN :

0333-1024

eISSN :

1468-2982

Publisher :

Blackwell Science

Volume :

Issue :

Suppl. 1

Pages :

13-31

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 28 September 2009

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1 (1 by ULiège)

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Scopus citations^®

144

Scopus citations^®
without self-citations

133

OpenCitations

111

OpenAlex citations

153

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