Article (Scientific journals)
Differential Expression of the 67-Kd Laminin Receptor and 31-Kd Human Laminin-Binding Protein in Human Ovarian Carcinomas
van den Brule, F. A.; Berchuck, A.; Bast, R. C. et al.
1994In European Journal of Cancer, 30A (8), p. 1096-9
Peer Reviewed verified by ORBi
 

Files


Full Text
VAN DEN BRULE FA EUR J CANCER 1994.PDF
Publisher postprint (3.7 MB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
ovarian cancer; laminin receptors
Abstract :
[en] The expression of the 67-kD laminin receptor (67LR) and the 31-kD human laminin-binding protein (HLBP31), two proteins involved in cancer cell laminin interaction, was evaluated on 30 ovarian cancer specimens. Expression of the 67LR was increased (up to 2.5-fold, in 87% of the patients), while HLBP31 expression was downregulated in cancer cells compared with the normal tissue, as detected by northern blotting and immunohistochemistry. The immunohistochemical study demonstrated that the 67LR was significantly overexpressed (P < 0.05) in the group of patients whose cytoreductive surgery was suboptimal, and those with poor clinical outcome. No correlation was observed between HLBP31 expression and clinicopathological features. Increased expression of the 67LR appears to correlate with the invasive phenotype of ovarian cancer cells and suggests a role of the latter in ovarian cancer invasion.
Disciplines :
Oncology
Biochemistry, biophysics & molecular biology
Author, co-author :
van den Brule, F. A.
Berchuck, A.
Bast, R. C.
Liu, F. T.
Gillet, C.
Sobel, M. E.
Castronovo, Vincenzo ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie générale et cellulaire
Language :
English
Title :
Differential Expression of the 67-Kd Laminin Receptor and 31-Kd Human Laminin-Binding Protein in Human Ovarian Carcinomas
Publication date :
1994
Journal title :
European Journal of Cancer
ISSN :
0959-8049
eISSN :
1879-0852
Publisher :
Elsevier, United Kingdom
Volume :
30A
Issue :
8
Pages :
1096-9
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
Fonds Léon Fredericq [BE]
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Télévie [BE]
BIOMED BMH1-CT92-0520
Available on ORBi :
since 28 September 2009

Statistics


Number of views
42 (1 by ULiège)
Number of downloads
1 (1 by ULiège)

Scopus citations®
 
112
Scopus citations®
without self-citations
92
OpenCitations
 
72

Bibliography


Similar publications



Contact ORBi