Relationship between the changes over time of bone mass and muscle health in children and adults: A systematic review and meta-analysis

Locquet, Médéa; Beaudart, Charlotte; Durieux, Nancy; Reginster, Jean-Yves; Bruyère, Olivier

doi:10.1186/s12891-019-2752-4

Article (Scientific journals)

Relationship between the changes over time of bone mass and muscle health in children and adults: A systematic review and meta-analysis

Locquet, Médéa; Beaudart, Charlotte; Durieux, Nancy et al.

2019 • In BMC Musculoskeletal Disorders, 20, p. 429

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/241242

DOI
10.1186/s12891-019-2752-4

PubMed
31521141

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Keywords :

Bone mineral density; Longitudinal; Meta-analysis; Muscle-bone unit; Musculoskeletal health; Review

Abstract :

[en] Background: Various cross-sectional studies provide an abundance of evidence that shows a relationship between bone quantity and muscle health. However, one question remains, less-often studied: is their development - or decline - associated? The aim of the research was to conduct a systematic review and meta-analysis to summarize the studies exploring the association between changes in bone mineral density (BMD) and changes in muscle parameters (registration CRD42018093813). Methods: We searched for prospective studies, both in children and adults, by consulting electronic databases (Ovid-MEDLINE, Ovid-AMED, Scopus). Each review steps were performed by two independent reviewers. For outcomes reported by less of 3 studies, we synthetized the results narratively. In other cases, a meta-analysis was performed, giving an overall r coefficient and its 95% confidence interval (CI). Results: Fifteen papers were included. In connection with the change of BMD, 10 studies concerned the parallel change of lean mass, 4 were about grip strength, and 1 was about physical performance. Children were the population of interest for 5 studies, while the aging population was the focus of the other studies. The correlation between hip BMD and lean mass was significant, with an overall coefficient r = 0.37 (95% CI 0.23-0.49). High heterogeneity was observed between studies but the length of follow-up, sex and study quality did not seem to significantly influence results. The systematic review allowed some other highlights: a significant link between changes in BMD and changes in muscle strength was observed (p-value < 0.05 in the 4 studies), in addition to changes in performance (1 study, r = 0.21, p-value = 0.004). Conclusion: Despite the heterogeneity between studies, we highlighted a significant association between the change of BMD and the change of various muscle parameters. Future studies should investigate preventive and therapeutic strategies that are based on a single entity: the 'muscle-bone unit'. © 2019 The Author(s).

Disciplines :

Public health, health care sciences & services

Author, co-author :

Locquet, Médéa ; Université de Liège - ULiège > Département des sciences de la santé publique > Epidémiologie clinique

Beaudart, Charlotte ; Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé

Durieux, Nancy ; Université de Liège - ULiège > Bibliothèque des Sciences de la vie

Reginster, Jean-Yves ; Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé

Bruyère, Olivier ; Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé

Language :

English

Title :

Relationship between the changes over time of bone mass and muscle health in children and adults: A systematic review and meta-analysis

Publication date :

2019

Journal title :

BMC Musculoskeletal Disorders

eISSN :

1471-2474

Publisher :

BioMed Central Ltd.

Volume :

Pages :

429

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 13 November 2019

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