Reference : Cerebellar metabolite alterations detected in vivo by proton MR spectroscopy
Scientific journals : Article
Human health sciences : Radiology, nuclear medicine & imaging
Cerebellar metabolite alterations detected in vivo by proton MR spectroscopy
Macri, M. A. [> > > >]
Garreffa, G. [> > > >]
Giove, F. [> > > >]
Ambrosini, A. [> > > >]
Guardati, M. [> > > >]
Pierelli, F. [> > > >]
Schoenen, Jean mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Neuro-anatomie]
Colonnese, C. [> > > >]
Maraviglia, B. [> > > >]
Magnetic Resonance Imaging
Elsevier Science Inc
Yes (verified by ORBi)
New York
[en] spectral analysis ; short TE H-1 MRS spectroscopy ; migraine
[en] The aim of our work was to evaluate the feasibility of in vivo single-voxel quantitative proton MR spectroscopy in order to identify possible alterations in the main metabolite concentrations due to some metabolic dysfunctions in the cerebellum of patients suffering from a particular form of migraine called "with aura." Measurements of metabolite levels in the cerebellum disclosed reduced choline values (normalized both to N-acetyl-aspartate and creatine) in the patient group with respect to the age-matched control group. Our interest in this pathology is motivated by the fact that there are no available specific biochemical markers for migraine characterization, and the current diagnostic only takes advantage of the medical history and the clinical examination. (C) 2003 Elsevier Inc. All rights reserved.

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