Treatment with long acting muscarinic antagonists stimulates serum levels of irisin in patients with COPD

Anticholinergics; Chronic obstructive pulmonary disease (COPD); Irisin; Long acting muscarinic receptor antagonist (LAMA); Article; Charlson Comorbidity Index; Short Form 36

Abstract :

[en] Long acting muscarinic antagonists (LAMA) are currently considered the therapeutic mainstay for patients with COPD and have been shown to improve clinical outcomes including symptoms, exercise capacity and airflow limitation. Irisin, is a newly discovered hormone-like myokine generated by skeletal muscle cells in response to exercise and it is suggested to regulate energy expenditure and exercise capacity. The aim of the present study was to investigate if treatment with LAMA alters serum irisin levels in patients with COPD. Irisin was assessed by ELISA in the serum of 506 patients with COPD, GOLD II-IV, with a smoking history >10 PY, who were included in the PROMISE-COPD cohort. The effect of inhaled LAMA on serum irisin levels was evaluated in a proof-of-concept cohort of 40 COPD patients. Univariate linear regression analysis revealed that there was a significant negative association of irisin with age-adjusted Charlson score (p = 0.003) and a positive association of irisin with 6-min walking distance (6MWD) (p = 0.018) and treatment with LAMA (p = 0.004) but not with LABA or ICS. Multivariate analysis revealed that the association of irisin with LAMA treatment remains significant after adjustment for age-adjusted score and 6MWD. In the proof-of-concept cohort a single inhalation of LAMA stimulated serum irisin levels after 4 h. These findings imply that treatment of COPD patients with LAMA increase circulating irisin, thus explaining some of the beneficial extra-pulmonary effects of these drugs when used in the treatment of COPD. © 2017

Disciplines :

Cardiovascular & respiratory systems

Author, co-author :

Mandal, Jyotshna; Clinic of Pulmonary Medicine, University Hospital Basel and Respiratory Cell Research, Department of Biomedicine, University of Basel, Basel, Switzerland

Roth, Michale; Clinic of Pulmonary Medicine, University Hospital Basel and Respiratory Cell Research, Department of Biomedicine, University of Basel, Basel, Switzerland

Papakonstantinou, Eleni; Clinic of Pulmonary Medicine, University Hospital Basel and Respiratory Cell Research, Department of Biomedicine, University of Basel, Basel, Switzerland

Sun, Qingzhu; Clinic of Pulmonary Medicine, University Hospital Basel and Respiratory Cell Research, Department of Biomedicine, University of Basel, Basel, Switzerland

Costa, Luigi; Clinic of Pulmonary Medicine, University Hospital Basel and Respiratory Cell Research, Department of Biomedicine, University of Basel, Basel, Switzerland

Boeck, Lucas; Clinic of Pulmonary Medicine, University Hospital Basel and Respiratory Cell Research, Department of Biomedicine, University of Basel, Basel, Switzerland

Scherr, Andreas; Clinic of Pulmonary Medicine, University Hospital Basel and Respiratory Cell Research, Department of Biomedicine, University of Basel, Basel, Switzerland

Rakic, Jean-Marie ; Université de Liège - ULiège > Département des sciences cliniques > Ophtalmologie

Louis, Renaud ; Université de Liège - ULiège > Département des sciences cliniques > Pneumologie - Allergologie

Milenkovic, B.; Pneumology, Institute for Pulmonary Diseases, Belgrade, Serbia

More authors (10 more)

Language :

English

Title :

Treatment with long acting muscarinic antagonists stimulates serum levels of irisin in patients with COPD

Publication date :

2018

Journal title :

Pulmonary Pharmacology and Therapeutics

ISSN :

1094-5539

eISSN :

1522-9629

Publisher :

Academic Press

Volume :

Pages :

111-116

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 12 November 2019

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