Poster (Scientific congresses and symposiums)
Continuous Flow Upgrading of Glycerol toward Oxiranes and Active Pharmaceutical Ingredients thereof
Morodo Martinez, Romain; Gerardy, Romaric; Petit, Guillaume et al.
20197th Conference on Frontiers in Organic Synthesis Technology
 

Files


Full Text
RMM_poster_FROST_v1.pdf
Author postprint (2.32 MB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Continous-flow; Biomass; Active pharmaceutical ingredient; Valorization; Intensification; Green chemistry; Organocatalysis; Platform molecules
Abstract :
[en] The progressive depletion of fossil resources and a global environmental awareness stimulates research toward a transition for more sustainable supplies. Glycerol, which is nowadays obtained as a by product of the biodiesel production, presents a significant industrial potential and can be upgraded in a large variety of value added building blocks. We present herein a robust multi module continuous flow procedure for the valorization of glycerol towards active pharmaceutical ingredients (through the intermediate formation of epichlorohydrin). The first module is dedicated to the valorization of glycerol into oxiranes by a hydrochlorination dechlorination concatenated sequence involving economically and environmentally favorable conditions, an organocatalyst and an in line separation of the two products. Finally, biobased epichlorohydrin is further utilized for the preparation of β-amino alcohol APIs including propranolol (WHO essential), naftopidil (prostatic hyperplasia) and alprenolol (angina pectoris) within a concatenable Williamson/ aminolysis sequence using a FDA class 3 solvent (DMSO).
Research center :
Center for Integrated Technology and Organic Synthesis
Disciplines :
Chemistry
Author, co-author :
Morodo Martinez, Romain  ;  Université de Liège - ULiège > Département de chimie (sciences) > Synthèse organique appliquée
Gerardy, Romaric ;  Université de Liège - ULiège > Département de chimie (sciences) > CITOS
Petit, Guillaume ;  Université de Liège - ULiège > Département de chimie (sciences) > Synthèse organique appliquée
Monbaliu, Jean-Christophe  ;  Université de Liège - ULiège > Département de chimie (sciences) > Synthèse organique appliquée
Language :
English
Title :
Continuous Flow Upgrading of Glycerol toward Oxiranes and Active Pharmaceutical Ingredients thereof
Publication date :
October 2019
Number of pages :
A0
Event name :
7th Conference on Frontiers in Organic Synthesis Technology
Event organizer :
Flow Chemistry Society
Event place :
Budapest, Hungary
Event date :
du 16 octobre 2019 au 18 octobre 2019
Audience :
International
Name of the research project :
Fluidic upgrading of biobased platforms
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
ULiège - Université de Liège [BE]
Available on ORBi :
since 07 November 2019

Statistics


Number of views
46 (5 by ULiège)
Number of downloads
1 (1 by ULiège)

Bibliography


Similar publications



Contact ORBi