[en] Twenty patients at early stages of Alzheimer's disease (AD), 20 elderly control subjects and 20 Young subjects completed a cross-form priming task, followed by a free recall task. Results show that patients with mild AD display priming effects and that these priming effects are strictly comparable to those obtained by elderly and young control subjects. Moreover, while the patients' performances are normal in the implicit part of the task, they are massively impaired in the explicit free recall task. These results don't support the hypothesis of a dissociation of performances between identification tasks and generation tasks in Alzheimer's disease and show that conceptual priming can be observed at early stages of the disease, despite semantic memory impairments.
Disciplines :
Neurosciences & behavior
Author, co-author :
Ergis, Anne-Marie; Institut National de la Santé et de la Recherche Médicale - INSERM
Van der Linden, Martial ; Université de Liège - ULiège > Département des sciences cognitives > Psychopathologie cognitive
DSM-III-R. Manuel Diagnostique et Statistique des Troubles Mentaux, Masson, Paris; 1987.
Bondi M.W., Kaszniak A.W. (1991) Implicit and explicit memory in Alzheimer's disease and Parkinson's disease. Journal of Clinical and Experimental Neuropsychology 13:339-358.
Brandt J., Spencer M., Mcsorley P., Folstein M.F. (1988) Semantic activation and implicit memory m Alzheimer's disease. Alzheimer's Disease and Associated Disorders 2:112-119.
Chiarello C., Hoyer W.J. (1988) Adult age differences in implicit and explicit memory: time course and encoding effects. Psychology and Aging 3:358-366.
Corkin S. (1982) Some relationships between global amnesias and the memory impairments in Alzheimer's disease. Alzheimer's Disease: A Report of Progress in Research, Raven Press, New York; .
Craik F.I.M., Jennings J.M. (1992) Human memory. The Handbook of Aging and Cognition, Lawrence Erlbaum Associates, Hillsdale, New Jersey; .
Davis H.P., Cohen A., Gandy M., Colombo P., Van Dusseldorp G., Simolke N., Romano J. (1990) Lexical priming deficits as a function of age. Behavioral Neuroscience 104:288-297.
Deweer B., Ergis A.M., Fossati P. (1991) Mémoire explicite et mémoire implicite dans la maladie d' Alzheimer. Mémoire et Vieillissement, Maloine, Paris; .
Deweer B., Ergis A.M., Fossati P., Pillon B., Boller F., Agid Y., Dubois B. (1994) Explicit memory, procedural learning and lexical priming in Alzheimer's disease. Cortex 30:113-126.
Engelkamp J., Zimmer H.D. The Human Memory. A Multimodal Approach, Hogrese and Huber, Seattle; 1994.
Ergis A.M., Deweer B., Fossati P. (1992) Explicit and implicit memory in Alzheimer's disease. Journal of Clinical and Experimental Neuropsychology 14:21.
.
Eslinger P.J., Damasio A.R. (1986) Preserved motor learning in Alzheimer's disease: implications for anatomy and behavior. The Journal of Neuroscience 6:3006-3009.
Folstein M.F., Folstein S.E., Mchugh P.R. (1975) “Mini Mental State”: a practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research 12:189-198.
Gabrieli J.D.E., Keane M.M., Stanger B.Z., Kjelgaard M.M., Corkin S., Growdon J.H. (1994) Dissociations among structural-perceptual, lexical-semantic, and event-fact memory systems in Alzheimer, amnesic, and normal subjects. Cortex 30:75-103.
Gewirth L., Shindler A., Hier D.B. (1984) Altered patterns of word association in dementia and aphasia. Brain and Language 21:307-317.
Gollin E.S. (1960) Developmental studies of visual recognition of incomplete objects. Perceptual and Motor Skills 11:289-298.
Grober E., Buschke H. (1987) Genuine memory deficits in dementia. Developmental Neuropsychology 3:13-36.
Grober E., Buschke H., Kawas C., Fuld P. (1985) Impaired ranking of semantic attributes in dementia. Brain and Language 26:276-286.
Grober E., Gitlin H.L., Bang S., Buschke H. (1992) Implicit and explicit memory in young, old, and demented adults. Journal of Clinical and Experimental Neuropsychology 14:298-316.
Grosse D.A., Wilson R.S., Fox J.H. (1990) Preserved word-stem-completion priming of semantically encoded information in Alzheimer's disease. Psychology and Aging 5:304-306.
Heindel W.C., Salmon D.P., Butters N. (1990) Pictorial priming and cued recall in Alzheimer's and Huntington's disease. Brain and Cognition 13:282-295.
Heindel W.C., Salmon D.P., Shults C.W., Walicke P.A., Butters N. (1989) Neuropsychological evidence for multiple implicit memory systems: a comparison of Alzheimer's, Huntington's and Parkinson's disease patients. The Journal of Neuroscience 9:582-587.
Hirshman E., Snodgrass J.G., Mindes J., Feenan K. (1990) Conceptual priming in fragment completion. Journal of Experimental Psychology: Learning, Memory and Cognition 16:634-647.
Huff F.J., Mack L., Mahlman J., Greenberg S. (1988) A comparison of lexical-semantic impairments in left hemisphere stroke and Alzheimer's disease. Brain and Language 34:262-278.
Jacoby L.L., Kelley C. (1992) Unconscious influences of memory: dissociations and automaticity. The Neuropsychology of Consciousness, Academic Press, London; .
Java R.I., Gardiner I.M. (1991) Priming and aging: further evidence of preserved memory function. American Journal of Psychology 104:89-100.
Kaszniak A.W., Poon L.W., Riege W. (1986) Assessing memory deficits: an information-processing approach. Handbook for Clinical Memory Assessment of Older Adults, American Psychological Association, Washington; .
Keane M.K., Gabrieli J.D.E., Growdon J.H., Corkin S. (1994) Priming in perceptual identification of pseudowords is normal in Alzheimer's disease. Neuropsychologia 32:343-356.
Keane M.M., Gabrieli J.D.E., Fennema A.D., Growdon J.H., Corkin S. (1991) Evidence for a dissociation between perceptual and conceptual priming in Alzheimer's disease. Behavioral Neuroscience 105:326-342.
Light L.L., Albertson S.A. (1989) Direct and indirect tests of memory for category exemplars in young and older adults. Psychology and Aging 4:487-492.
Light L.L., Singh A. (1987) Implicit and explicit memory in young and older adults. Journal of Experimental Psychology: Learning, Memory and Cognition 13:531-541.
Light L.L., Singh A., Capps J.L. (1986) The dissociation of memory and awareness in young and older adults. Journal of Clinical Neuropsychology 8:62-74.
Lussier I., Belleville S., Peretz I., Fontaine F., Chatelois J., Vander Linden M. (1990) Preserved implicit memory in patients with dementia of the Alzheimer's type. Journal of Clinical and Experimental Neuropsychology 12:19.
Martin A., Brouwers P., Cox C., Fedio P. (1985) On the nature of the verbal memory deficit in Alzheimer's disease. Journal of Clinical and Experimental Neuropsycology 9:191-224.
Martin A., Fedio P. (1983) Word production and comprehension in Alzheimer's disease: The breakdown of semantic knowledge. Brain and Language 19:124-141.
Mattis S. (1976) Mental status examination for organic mental syndrome in the elderly patient. Geriatric Psychiatry, Grune and Stratton, New-York; .
McKhann G., Drachman D., Folstein M., Katzman R., Price D., Stadlan E.M. (1984) Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease. Neurology 34:939-944.
Mitchell D.B. (1989) How many memory systems? Evidence from aging. Journal of Experimental Psychology: Learning, Memory and Cognition 15:31-49.
Mitchell D.B., Brown D.S., Murphy D.R. (1990) Procedural and episodic memory: dissociations produced by time and aging. Psychology and Aging 5:264-276.
Montgomery S.A., Asberg M. (1979) A new depression scale designed to be sensitive to change. British Journal of Psychiatry 134:382-389.
Monti L.A., Gabrieli J.D.E., Wilson R.S., Reminger S.L. (1994) Intact text-specific implicit memory in patients with Alzheimer's disease. Psychology and Aging 9:64-71.
Moscovitch M., Winocur G. (1992) The neuropsychology of memory and aging. The Handbook of Aging and Cognition, Lawrence Erlbaum Associates, Hillsdale, New Jersey; .
Moscovitch M., Winocur G., McLachlan D. (1986) Memory as assessed by recognition and reading time in normal and memory-impaired people with Alzheimer's disease and other neurological disorders. Journal of Experimental Psychology: General 115:331-347.
Nebes R.D. (1992) Cognitive dysfunction in Alzheimer's disease. The Handbook of Aging and Cognition, Lawrence Erlbaum Associates, Hillsdale, New Jersey; .
Nelson D.L., Schreiber A., Holley P.E. (1992) The retrieval of controlled and automatic aspects of meaning on direct and indirect tests. Memory and Cognition 20:671-684.
Partridge F.M., Knight R.G., Feehan M. (1990) Direct and indirect memory performance in patients with senile dementia. Psychological Medicine 20:111-118.
Roediger H.L., McDermott K.B. (1993) Implicit memory in normal human subjects. Handbook of Neuropsychology , Elsevier, Amsterdam; 63-131.
Roediger H.L., Weldon M.S., Challis B.H. (1989) Explaining dissociations between implicit and explicit measures of retention: a processing account. Varieties of Memory and Consciousness: Essays in Honour of Endel Tulving, Lawrence Erlbaum, Hillsdale, N.J.; .
Salmon D.P., Heindel W.C. Impaired priming in Alzheimer's disease: neuropsychological implications. Neuropsychology of Memory, 2nd ed, The Guilford Press, New York; 1992.
Salmon D.P., Shimamura A.P., Butters N., Smith S. (1988) Lexical and semantic priming deficits in patients with Alzheimer's disease. Journal of Clinical and Experimental Neuropsychology 10:477-494.
Schacter D.L. (1987) Implicit memory: history and current status. Journal of Experimental Psychology: Learning, Memory and Cognition 13:501-518.
Shimamura A.P., Salmon D.P., Squire L.R., Butters N. (1987) Memory dysfunction and word priming in dementia and amnesia. Behavioral Neuroscience 101:347-351.
Snodgrass J.G. (1989) Sources of learning in the picture fragment completion task. Implicit Memory: Theoretical Issues, Lawrence Erlbaum Associates, Hillsdale, New Jersey; .
Snodgrass L.G., Smith B., Feenan K., Corwin J. (1987) Fragmenting pictures on the Apple Macintosh computer for experimental and clinical applications. Behavior Research Methods, Instruments, & Computers 270-274.
Snodgrass J.G., Vanderwart M. (1980) A standardized set of 260 pictures: norms for naming agreement, familiarity, and visual complexity. Journal of Experimental Psychology: Human Learning and Memory 6:174-215.
Snodgrass T.A., Corwin J. (1988) Pragmatics of measuring recognition memory: Applications to dementia and amnesia. Journal of Experimental Psychology: General 117:34-50.
Tulving E., Schacter D.L. (1990) Priming and human memory systems. Science 247:301-306.
Van der Linden M. (1994) Mémoire à long terme et vieillissement. Le vieillissement cognitif, Presses Universitaires de France, Paris; .
Van der Linden M., Bruyer R., Devloo J.F. (1993) Aging and cross-modal priming in fragment completion. Workshop on Memory in normal aging and dementia, Toronto, Abstract; .