Estimation and identification issues in the promotion time cure model when the same covariates influence long- and short-term survival

Lambert, Philippe; Bremhorst, Vincent

doi:10.1002/bimj.201700250

Article (Scientific journals)

Estimation and identification issues in the promotion time cure model when the same covariates influence long- and short-term survival

Lambert, Philippe; Bremhorst, Vincent

2019 • In Biometrical Journal, 61 (2), p. 275-289

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/240975

DOI
10.1002/bimj.201700250

PubMed
30345588

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Keywords :

Bayesian P-splines; Cure model; Identification issues; Insufficiently long follow-up; Survival analysis

Abstract :

[en] The promotion time cure model is a survival model acknowledging that an unidentified proportion of subjects will never experience the event of interest whatever the duration of the follow-up. We focus our interest on the challenges raised by the strong posterior correlation between some of the regression parameters when the same covariates influence long- and short-term survival. Then, the regression parameters of shared covariates are strongly correlated with, in addition, identification issues when the maximum follow-up duration is insufficiently long to identify the cured fraction. We investigate how, despite this, plausible values for these parameters can be obtained in a computationally efficient way. The theoretical properties of our strategy will be investigated by simulation and illustrated on clinical data. Practical recommendations will also be made for the analysis of survival data known to include an unidentified cured fraction. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Disciplines :

Mathematics

Author, co-author :

Lambert, Philippe ; Université de Liège - ULiège > Faculté des sciences sociales > Méthodes quantitatives en sciences sociales

Bremhorst, Vincent; Institut de statistique, biostatistique et sciences actuarielles (ISBA), Université catholique de Louvain, Louvain-la-Neuve, B-1348, Belgium

Language :

English

Title :

Estimation and identification issues in the promotion time cure model when the same covariates influence long- and short-term survival

Publication date :

2019

Journal title :

Biometrical Journal

ISSN :

0323-3847

eISSN :

1521-4036

Publisher :

Wiley-VCH Verlag

Volume :

Issue :

Pages :

275-289

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85055255286&doi=10.1002%2fbimj.201700250&partnerID=40&md5=11dfcb0c03de719d63536a02935de58f

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