[en] The basis of amnesia in alcoholic Wernicke-Korsakoff syndrome (WKS) has been generally associated with diencephalic lesions and more specifically with lesions of the anterior thalamic nuclei. These brain structures are considered to be involved in encoding/consolidation processes of episodic memory. However, frontal lobe damage responsible for executive function deficits has
also been documented. The present report details the nature and extent of amnesia in an alcoholic patients with WKS and which appears to be mainly due to frontal lobe (executive) deficits.
Disciplines :
Neurosciences & behavior
Author, co-author :
Noël, Xavier ; Université de Liège - ULiège > Département des sciences cognitives > Département des sciences cognitives
Schmidt, Nicolas
Van der Linden, Martial ; Université de Liège - ULiège > Département des sciences cognitives > Psychopathologie cognitive
Sferrazza, Rita
Hanak, Catherine
De Mol, Jacques
Kornreich, C.
Pelc, Isy
Verbanck, Paul
Language :
English
Title :
An atypical neuropsychological profile of a Korsakoff syndrome patient throughout the follow-up
Korsakoff S.S. (1889) Etude médico-psychologique sur une forme des maladies de la mémoire. Rev Philos 24:501-530.
Alexander L. (1940) Wernicke's disease: Identity of lesions produced experimentally by B1 avitaminosis in pigeons with haemorrhagic polioen-cephalitis occurring in chronic alcoholism in man. Am J Pathol 16:61-70.
Darnton-Hill I., Truswell A.S. (1990) Thiamin status of a sample of homeless clinic attenders in Sydney. Med J Aust 152:5-9.
Kopelman M.D. (1995) The Korsakoff syndrome. Br J Psychiatry 166:154-173.
Harper C.G. (1983) The incidence of Wernicke's encephalopathy in Australia - A neuropathological study of 131 cases. J Neurol Neurosurg Psychiatry 46:593-598.
Mair W.G., Warrington E.K., Weiskrantz L. (1979) Locations of lesions in Korsakoff's syndrome: Neuropsychological and neuropathological investigation of two cases. Brain 102:749-783.
Victor M., Amans R.D., Collins G.H. The Wernicke-Korsakoff Syndrome and Related Neurological Disorders Due to Alcoholism and Malnutrition, Philadelphia, Davis; 1989.
Harding A., Halliday G., Caine D., Kril J. (2000) Degeneration of anterior thalamic nuclei differentiates alcoholics with amnesia. Brain 123:141-154.
Joyce E.M., Rio D.E., Ruttimann U.E. (1994) Decreased cingulated and precuneate glucose utilization in alcoholic Korsakoff's syndrome. Psychiatry Res 54:225-239.
Kril J., Halliday G.M., Svoboda M.D., Cartwright H. (1997) The cerebral cortex is damaged in chronic alcoholics. Neuroscience 79:983-998.
Shimamura A.P., Jernigan T.L., Squire L. (1988) Korsakoff's syndrome: Radiological (CT) findings and neuropsychological correlates. J Neurosci 8:4400-4410.
Fazio F., Perani D., Gilardi M.C. (1992) Metabolic impairment in human amnesia: A PET study of memory networks. J Cereb Blood Flow Metab 12:353-358.
Arendt T., Bigl V., Arendt A. (1983) Loss of neurons in the nucleus basalis of Meynert in Alzheimer's disease, paralysis agitans and Korsakoff's disease. Acta Neuropathol 61:101-108.
Mayes A.R., Meudell P.R., Mann D. (1988) Location of lesions in Korsakoff's syndrome: Neuropsychological and neuropathological data on two patients. Cortex 24:367-388.
Squire L.R., Haist R., Shimamura A.P. (1989) The neurology of memory: Quantitative assessment of retrograde amnesia in two types of amnesic patients. J Neurosci 9:828-839.
Butter N., Cermak L.S. Alcoholic Korsakoff's Syndrome: An Information-Processing Approach to Amnesia, New York, Academic Press; 1980.
Kupfermann I. (1991) Learning and memory. Principles of Neural Science , Kandel RR (ed). Connecticut, Appleton & Lange; 997-1008.
Warrington E., Weiskrantz L. (1970) Amnesic syndrome: Consolidation or retrieval?. Nature 228:628-630.
Baddeley A.D. Working memory, Oxford, Oxford University Press; 1986.
Kopelman M.D. (1987) Two types of confabulation. J Neurol Neurosurg Psychiatry 50:1482-1487.
Stanhope N., Guinan E., Kopelman M.D. (1998) Frequency judgments of abstract designs by patients with diencephalic, temporal lobe or frontal lobe lesions. Neuropsychologia 36:1387-1396.
Oscar-Berman M. (1973) Hypothesis testing and focusing behavior during concept formation by amnesic Korsakoff patients. Neuropsychologia 11:191-198.
Joyce E.M., Robbins T.W. (1991) Frontal lobe function in Korsakoff and non-Korsakoff alcoholics: Planning and spatial working memory. Neuropsychologia 29:709-723.
Jacobson R.R., Acker C.F., Lishman W.A. (1990) Patterns of neuropsychological deficit in alcoholic Korsakoff's syndrome. Psychol Med 20:321-334.
Pollux P.M.J., Wester A., De Haan E.H.F. (1995) Random generation deficit in alcoholic Korsakoff patients. Neuropsychologia 33:125-129.
Harding A., Halliday G., Caine D., Kril J. (2000) Degeneration of anterior thalamic nuclei differentiates alcoholics with amnesia. Brain 123:141-154.
Visser P.J., Krabbendam L., Verhey F.R.J., Hofman P.A.M., Verhoeven W.M.A., Tuinier S., Wester A., Van Den Berg Y.W.M.M., Goessens L.F.M., Van Der Werf Y.D., Jolles J. (1999) Brain correlates of memory dysfunction in alcoholic Korsakoff's syndrome. J Neurol Neurosurg Psychiatry 67:774-778.
Kopelman M.D. (1991) Frontal lobe dysfunction and memory deficits in the alcoholic Korsakoff syndrome and Alzheimer-type dementia. Brain 114:117-137.
Kopelman M.D. (1992) The 'new' and the 'old': Components of the anterograde and retrograde memory loss in Korsakoff and Alzheimer patients. The Neuropsychology of Memory , Squire IR, Butters N (eds). New York, Guilford; 130-146.
Jacobson R.R., Lishman W. (1987) Selective memory loss and global intellectual deficits in alcoholic Korsakoff's syndrome. Psychol Med 17:649-655.
Welch L.W., Nimmerrichter A., Kessler R. (1996) Severe global amnesia presenting as Wernicke-Korsakoff syndrome but resulting from atypical lesions. Psychol Med 26:421-425.
Harper C.G., Sheedy D.L., Lara A.I., Garrick T.M., Hilton J.M., Raisanen J. (1998) Prevalence of Wernicke-Korsakoff syndrome in Australia: Has thiamine fortification made a difference?. Med J Aust 168:542-545.
Caine D., Halliday G.M., Kril J.J., Harper C.G. (1997) Operational criteria for the classification of chronic alcoholics: Identification of Wernicke's encephalopathy. J Neurol Neurosurg Psychiatry 62:51-60.
Diagnostic and Statistical Manual of Mental disorders, Washington, American Psychiatric Press; 1994.
Harper C., Gold J., Rodriguez M., Perdices M. (1989) The prevalence of Wernicke-Korsakoff in Sydney, Australia: A prospective necropsy study. J Neurol Neurosurg Psychiatry 52:282-285.
Raven J. Guide to the Standard Progressive Matrices, London, Lewis; 1960.
Brown J. (1958) Some tests of the decay theory of immediate memory. Q J Exp Psychol 10:12-21.
Peterson L.R., Peterson M.F. (1959) Short term retention of individual verbal items. J Exp Psychol 58:193-198.
Belleville S., Rouleau N., Caza N. (1998) Effect of normal aging on the manipulation of information in working memory. Mem Cognit 26:572-583.
Delis D.C., Kramer J.G., Kaplan E., Ober B.A. The California Verbal Learning Test, New York, Psychological Corporation; 1987.
Delis D.C., Freeland J., Kramer J.G., Kaplan E. (1988) Integrating clinical assessment with cognitive neuroscience. Construct validation of the California Verbal Learning Test. J Consult Clin Psychol 46:123-130.
Deweer B., Benoit N., Coyette F., Dubois B., Ergis A.M., Eustache F., Hahn-Barma V., Hugonot L., Kalafat M., Le Roch K., Marié R.M., Pasquier F., Pillon B., Poitrenaud J., Van der Linden M. Adaptation en langue française du California Verbal Learning Test, In preparation; .
Buschke H. (1973) Selective reminding for analysis of memory and learning. J Verbal Learn Verbal Behav 12:543-550.
Wickens D. (1970) Encoding categories of words: An empirical approach to memory. Psychol Rev 77:1-15.
Rey A. L'examen clinique en psychologie, Paris, Presses Universitaires de France; 1970.
Grattan L.M., Eslinger P.F. (1989) Higher cognition and social behavior: Changes in cognitive flexibility and empathy alter cerebral lesions. Neuropsychology 3:175-185.
Eslinger P.J., Grattan L.M. (1993) Frontal lobe and frontal-striatal substrates for different forms of human cognitive flexibility. Neuropsychologia 31:17-28.
Milner B. (1964) Some effects of frontal lobectomy in man. Frontal Granular Cortex and Behavior , Warren JM, Akert K (eds). New York, McGraw-Hill; 313-331.
Perret E. (1974) The left frontal lobe of man and the suppression of habitual responses in verbal categorical behaviour. Neuropsychologia 20:29-262.
Reitan R.M. (1958) Validity of the Trail-Making Test as an indicator of organic brain damage. Percept Mot Skills 8:271-276.
Burgess P.W., Shallice T. (1996) Response suppression, initiation and strategy use following frontal lobe lesions. Neuropsychologia 34:263-273.
Burgess P.W., Shallice T. (1996) Bizarre responses, rule detection and frontal lobe lesions. Cortex 32:241-259.
Shallice T. (1982) Specific impairments of planning. Philos Trans R Soc Lond 298:199-209.
Brickenkamp R. Test d2: Aufmerksamkeits-Belastungs-Test (Handanweisung, 7th ed), Göttingen, Hogrefe; 1988.
D'Esposito M.E., Detre J.A., Alsop D.C., Shin R.K., Atlas S., Grossman M. (1995) The neural basis of the central executive system of working memory. Nature 378:279-281.
Collette F., Salmon E., Van der Linden M. (1999) Regional brain activity during tasks devoted to the central executive of working memory. Brain Res Cogn Brain Res 7:411-417.
Gershberg F.B., Shimamura A.P. (1995) Impaired use of organizational strategies in free recall following frontal lobe damage. Neuropsychologia 13:1305-1333.
Shallice T. From neuropsychology to mental structure, Cambridge, Cambridge University Press; 1988.
Parkin A.J., Binschaedler C., Harsent L., Metzler C. (1996) Pathological false alarm rates following damage to the left frontal cortex. Brain Cogn 5:326-343.
Norman K.A., Schacter D.L. (1996) Implicit memory, explicit memory, and false recollection: A cognitive neuroscience perspective. Implicit Memory and Metacognition , Reder LM (ed). Mahwah, Erlbaum; 229-257.
Shimamura A.P., Jurica P.F., Mangels J.A., Gershberg F.B., Knight R.T. (1995) Susceptibility to memory interference effects following frontal lobe damage: Findings from tests of paired-associate learning. J Cogn Neurosci 7:144-153.
Collette F., Van der Linden M., Delfiore G., Degueldre C., Salmon E. (1999) The functional anatomy of inhibition processes investigated with the Hayling task. J Neurol 246.
Tarter R.E. (1973) An analysis of cognitive deficits in chronic alcoholics. J Nerv Ment Disord 157:138-147.