Article (Scientific journals)
Hoxc5 and Hoxc8 Expression Are Selectively Turned on in Human Cervical Cancer Cells Compared to Normal Keratinocytes
Alami, Y.; Castronovo, Vincenzo; Belotti, D. et al.
1999In Biochemical and Biophysical Research Communications, 257 (3), p. 738-45
Peer reviewed
 

Files


Full Text
ALAMI BIOCHEM BIOPHYS RES COMMUN 1999.pdf
Publisher postprint (210.14 kB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
HOX; keratinocytes
Abstract :
[en] A growing number of data have sustained the involvement of homeobox genes expression deregulation in cancer. In this study, we have performed an exhaustive survey of the expression of the 39 class I HOX genes expressed in normal and malignant human cervix keratinocytes. Using RT-PCR, we observed that the vast majority (34/39) of HOX genes are expressed in normal keratinocytes. Only HOXA2, HOXA7, HOXC5, HOXC8 and HOXD12 were found to be silent. Interestingly, this pattern is conserved in the transformed keratinocytes (SiHa cells) except for the appearance of HOXC5 and HOXC8 mRNA. The HOXC5 and HOXC8 expression was also observed in two other transformed keratinocytes cell lines of independent origins, Eil-8 and 18-11S3, and confirmed by in situ hybridization. Our data add weight to the body of evidence attributing to a specific adult tissue a particular combination of expressed HOX genes and suggest that HOXC5 and/or HOXC8 could be involved in the process leading to the transformation of cervical keratinocytes.
Disciplines :
Biochemistry, biophysics & molecular biology
Oncology
Author, co-author :
Alami, Y.
Castronovo, Vincenzo ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie générale et cellulaire
Belotti, D.
Flagiello, D.
Clausse, Nathalie
Language :
English
Title :
Hoxc5 and Hoxc8 Expression Are Selectively Turned on in Human Cervical Cancer Cells Compared to Normal Keratinocytes
Publication date :
21 April 1999
Journal title :
Biochemical and Biophysical Research Communications
ISSN :
0006-291X
eISSN :
1090-2104
Publisher :
Elsevier, Atlanta, United States - California
Volume :
257
Issue :
3
Pages :
738-45
Peer reviewed :
Peer reviewed
Name of the research project :
ARC - Actions de recherche concertées N°96/00-191
Funders :
Télévie [BE]
FWB - Fédération Wallonie-Bruxelles [BE]
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Association Sportive contre le Cancer
Available on ORBi :
since 28 September 2009

Statistics


Number of views
45 (4 by ULiège)
Number of downloads
0 (0 by ULiège)

Scopus citations®
 
70
Scopus citations®
without self-citations
69
OpenCitations
 
56

Bibliography


Similar publications



Contact ORBi