Article (Scientific journals)
Galectin-3 and Cancer (Review)
Califice, Stéphane; Castronovo, Vincenzo; van den Brûle, Fréderic
2004In International Journal of Oncology, 25 (4), p. 983-92
Peer Reviewed verified by ORBi
 

Files


Full Text
CALIFICE INT J ONCOL 2004.pdf
Publisher postprint (496.42 kB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
cancer; galectin-3; extracellular matrix
Abstract :
[en] Galectin-3 is a pleiotropic carbohydrate-binding protein involved in a variety of normal and pathological biological processes. Its carbohydrate-binding properties constitute the basis for cell-cell and cell-matrix interactions and cancer progression. Modulation of galectin-3 expression in cancer cells has indeed been reported. These observations lead to the recognition of galectin-3 as a diagnostic/prognostic marker for specific cancer types, such as thyroid and prostate. This review discusses the expression and cellular localization of galectin-3 in cancer cells, as well as its numerous functions in cancer cell biology, including cell-cell adhesion, cell-matrix interactions, growth regulation, apoptosis, angiogenesis and mRNA splicing.
Disciplines :
Oncology
Biochemistry, biophysics & molecular biology
Author, co-author :
Califice, Stéphane;  Université de Liège - ULiège > Laboratoire de Recherche sur les Métastases
Castronovo, Vincenzo ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie générale et cellulaire - GIGA-R : Labo de recherche sur les métastases
van den Brûle, Fréderic;  Université de Liège - ULiège > Laboratoire de Recherche sur les Métastases
Language :
English
Title :
Galectin-3 and Cancer (Review)
Publication date :
October 2004
Journal title :
International Journal of Oncology
ISSN :
1019-6439
eISSN :
1791-2423
Publisher :
Demetrios A. Spandidos Ed. & Pub., Greece
Volume :
25
Issue :
4
Pages :
983-92
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Fonds de la Recherche Médicale
Télévie [BE]
Association Sportive Contre le Cancer
Fonds Léon Fredericq [BE]
Available on ORBi :
since 28 September 2009

Statistics


Number of views
116 (4 by ULiège)
Number of downloads
2 (0 by ULiège)

Scopus citations®
 
149
Scopus citations®
without self-citations
149

Bibliography


Similar publications



Contact ORBi