Unpublished conference/Abstract (Scientific congresses and symposiums)
A clinical and research 3T MRI protocol under 30 minutes
Larroque, Stephen Karl; Carrière, Manon; Martial, Charlotte et al.
201913th CME International Conference on Complex Medical Engineering
Peer reviewed


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Keywords :
magnetic resonance imagery; mri; fmri; disorders of consciousness; doc; lesions; optimization; multiband; multi-shell; DTI; DWI; FLAWS; MPRAGE; MP2RAGE; motion artefacts
Abstract :
[en] In the past decades, non-invasive neuroimaging allowed significant progress in the understanding of all neuroscientific domains from neuroanatomy to neurofunctional connectomes. Magnetic resonance imagery (MRI) is an ubiquitous tool nowadays, being available in most hospitals, which allows a wide array of imaging contrasts, from structural anatomy and connectivity, to functional connectivity and blood flow imaging. Although MRI is widely used for both clinical and research purposes, the relative protocols are often very different, to fulfill different and seemingly irreconcilable needs: clinical pertinence and time efficiency in the clinical setting with a total acquisition time often strictly restricted below 30 minutes per patient slot, whereas research MRI has more flexibility and more cutting-edge needs, with total acquisition time reaching up to 2h for a single subject, allowing to acquire complex sequences like multi-shell DTI. Furthermore, the targeted populations are often fundamentally different: uncooperative or motor uncontrolling patients for clinical are quite common, inducing motion artifacts, patient discomfort or even panic if the acquisition is too long, whereas research often is done on healthy volunteers who well understand the study instructions and can remain still for a long period of time. During this session, we will present a new 3T MRI protocol that can be used for both clinical and research purposes, and which has been successfully applied on uncollaborative and very motion prone patients with disorders of consciousness. This protocol is acquired in less than 30 minutes, and can thus be implemented on a clinical machine. The acquisition speed also reduces motion artifacts. We will demonstrate how we implemented and cursorily analyzed the sequences of this protocol, including multi-shell DTI for structural connectivity without T1 constraints, FLAWS MP2RAGE for physiologically segmented grey and white matter without computional approximations and sub-second EPI BOLD for dynamic functional connectivity analyses, as well as SWI MIP and FLAIR for clinical purposes or lesional studies. Furthermore, meta-protocol procedures will be described to support and enhance acquisitions in uncooperative patients, such as the use of innovative 3D axis motion reducing pillows like the Pearltec MultiPad and the importance of protocol programming such as sequence ordering and name changing on if-conditions. We hope this state-of-the-art protocol will allow clinicians and researchers alike to consider new opportunities in the optimization of MRI protocols as a mean to push beyond this seeming dichotomy.
Research Center/Unit :
Disciplines :
Laboratory medicine & medical technology
Author, co-author :
Larroque, Stephen Karl  ;  Université de Liège - ULiège > Consciousness-Coma Science Group
Carrière, Manon ;  Université de Liège - ULiège > Consciousness-Coma Science Group
Martial, Charlotte  ;  Université de Liège - ULiège > Consciousness-Coma Science Group
Laureys, Steven  ;  Université de Liège - ULiège > Consciousness-Coma Science Group
Language :
Title :
A clinical and research 3T MRI protocol under 30 minutes
Alternative titles :
[en] Un protocole IRM 3T pour la recherche et la pratique clinique en moins de 30 minutes
Publication date :
23 September 2019
Event name :
13th CME International Conference on Complex Medical Engineering
Event organizer :
Leibniz Research Centre for Working Environment and Human Factors, IfADo
Event place :
Dortmund, Germany
Event date :
from 23th September 2019 to 25th September 2019
Audience :
Peer reviewed :
Peer reviewed
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Available on ORBi :
since 27 October 2019


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