Article (Scientific journals)
Biomarkers of neonatal stress assessment: A prospective study.
ROUATBI, Hatem; Zigabe, Serge; Gkiougki, Eva et al.
2019In Early Human Development, 137, p. 104826
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Keywords :
Biomarkers; Birth stress; Copeptin; Myocardial damage; Perinatal asphyxia; Troponins
Abstract :
[en] INTRODUCTION: Early diagnosis of perinatal asphyxia, the major cause of neonatal mortality and morbidity, might be improved by the detection of neonatal stress biomarkers such as cardiac troponin (CTn)T, CTnI, NT-Terminal-pro-Brain Natriuretic Peptide (NT-pro-BNP), copeptin, and high sensitivity C-reactive protein (hs-CRP). However, reference values in neonates are lacking. The objective of our study was therefore to establish a reference range of these biomarkers in healthy full term newborns and to analyze the influence of delivery mode on their cord blood concentrations. PATIENTS AND METHODS: CTnT, CTnI, NT-pro-BNP, Copeptin and hs-CRP levels were determined in 201 neonates enrolled in this prospective study and correlated to the delivery mode and post-natal outcome. RESULTS: Using the 99th percentile, the upper reference limit in healthy newborns was established for all biomarkers. Neonates born after complicated delivery had significantly higher values of CTnT, CTnI and Copeptin than those born after uncomplicated delivery. In the multiple regression models with CTnT as dependent variable, the delivery mode was the statistically significant independent variable. CONCLUSION: In this study, we established reference values of cord blood concentrations of cardiac stress biomarkers in healthy newborns. We showed that cardiac-related birth stress is dependent on delivery mode.
Disciplines :
Author, co-author :
ROUATBI, Hatem ;  Centre Hospitalier Universitaire de Liège - CHU > Département de Pédiatrie > Service de pédiatrie
Zigabe, Serge;  Centre Hospitalier Universitaire de Liège - CHU > Pédiatrie > Pédiatrie
Gkiougki, Eva;  Centre Hospitalier Universitaire de Liège - CHU > Pédiatrie
VRANKEN, Laura ;  Centre Hospitalier Universitaire de Liège - CHU > Unilab > Secteur commun NDB
VAN LINTHOUT, Christine ;  Centre Hospitalier Universitaire de Liège - CHU > Département de gynécologie-obstétrique > Secteur obstétrique
Seghaye, Marie-Christine ;  Université de Liège - ULiège > Département des sciences cliniques > Pédiatrie cardiologique et pneumologique
Language :
Title :
Biomarkers of neonatal stress assessment: A prospective study.
Publication date :
October 2019
Journal title :
Early Human Development
Publisher :
Elsevier, Netherlands
Volume :
Pages :
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Copyright (c) 2019 Elsevier B.V. All rights reserved.
Available on ORBi :
since 15 October 2019


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