Achterman, R.R., Moyes, D.L., Thavaraj, S., Smith, A.R., Blair, K.M., White, T.C., et al. Dermatophytes activate skin keratinocytes via mitogen-activated protein kinase signaling and induce immune responses. Infect Immun 83 (2015), 1705–1714.
Aljabre, S.H., Richardson, M.D., Scott, E.M., Shankland, G.S., Germination of Trichophyton mentagrophytes on human stratum corneum in vitro. J Med Vet Mycol 30 (1992), 145–152.
Almeida, M.C., Brand, A.C., Thigmo responses: the fungal sense of touch. Microbiol Spectr, 5, 2017 FUNK-0040–2016.
Baldo, A., Mathy, A., Tabart, J., Camponova, P., Vermout, S., Massart, L., et al. Secreted subtilisin Sub3 from Microsporum canis is required for adherence to but not for invasion of the epidermis. Br J Dermatol 162 (2010), 990–997.
Bäsler, K., Bergmann, S., Heisig, M., Naegel, A., Zorn-Kruppa, M., Brandner, J.M., The role of tight junctions in skin barrier function and dermal absorption. J Control Release 242 (2016), 105–118.
Bäsler, K., Galliano, M.F., Bergmann, S., Rohde, H., Wladykowski, E., Vidal-y-Sy, S., et al. Biphasic influence of Staphylococcus aureus on human epidermal tight junctions. Ann N Y Acad Sci 1405 (2017), 53–70.
Brandner, J.M., Importance of tight junctions in relation to skin barrier function. Curr Probl Dermatol 49 (2016), 27–37.
Brasch, J., Mörig, A., Neumann, B., Proksch, E., Expression of antimicrobial peptides and toll-like receptors is increased in tinea and pityriasis versicolor. Mycoses 57 (2014), 147–152.
Brouta, F., Descamps, F., Vermout, S., Monod, M., Losson, B., Mignon, B., Humoral and cellular immune response to a Microsporum canis recombinant keratinolytic metalloprotease (r-MEP3) in experimentally infected guinea pigs. Med Mycol 41 (2003), 495–501.
Burstein, V.L., Guasconi, L., Beccacece, I., Theumer, M.G., Mena, C., Prinz, I., et al. IL-17-mediated immunity controls skin infection and T helper 1 response during experimental Microsporum canis dermatophytosis. J Invest Dermatol 138 (2018), 1744–1753.
Calderon, R.A., Hay, R.J., Cell-mediated immunity in experimental murine dermatophytosis. II. Adoptive transfer of immunity to dermatophyte infection by lymphoid cells from donors with acute or chronic infections. Immunology 53 (1984), 465–472.
Cambier, L., Weatherspoon, A., Defaweux, V., Bagut, E.T., Heinen, M.P., Antoine, N., et al. Assessment of the cutaneous immune response during Arthroderma benhamiae and A. vanbreuseghemii infection using an experimental mouse model. Br J Dermatol 170 (2014), 625–633.
Cambier, L.C., Heinen, M.P., Bagut, E.T., Antoine, N.A., Mignon, B.R., Overexpression of TLR-2 and TLR-4 mRNA in feline polymorphonuclear neutrophils exposed to Microsporum canis. Vet Dermatol 27 (2016), 78–81e22.
Campos, M.R., Russo, M., Gomes, E., Almeida, S.R., Stimulation, inhibition and death of macrophages infected with Trichophyton rubrum. Microbes Infect 8 (2006), 372–379.
De Vuyst, E., Charlier, C., Giltaire, S., De Glas, V., de Rouvroit, C.L., Poumay, Y., Reconstruction of normal and pathological human epidermis on polycarbonate filter. Methods Mol Biol 1195 (2014), 191–201.
Descamps, F., Brouta, F., Vermout, S., Monod, M., Losson, B., Mignon, B., Recombinant expression and antigenic properties of a 31.5-kDa keratinolytic subtilisin-like serine protease from Microsporum canis. FEMS Immunol Med Microbiol 38 (2003), 29–34.
Duek, L., Kaufman, G., Ulman, Y., Berdicevsky, I., The pathogenesis of dermatophyte infections in human skin sections. J Infect 48 (2004), 175–180.
Faway, É., Cambier, L., Mignon, B., Poumay, Y., Lambert de Rouvroit, C., Modeling dermatophytosis in reconstructed human epidermis: a new tool to study infection mechanisms and to test antifungal agents. Med Mycol 55 (2017), 485–494.
Firat, Y.H., Simanski, M., Rademacher, F., Schröder, L., Brasch, J., Harder, J., Infection of keratinocytes with Trichophyton rubrum induces epidermal growth factor-dependent RNase 7 and human beta-defensin-3 expression. PLOS ONE, 9, 2014, e93941.
García-Madrid, L., Huizar-López, M., Flores-Romo, L., Islas-Rodríguez, A., Trichophyton rubrum manipulates the innate immune functions of human keratinocytes. Cent Eur J Biol 6 (2011), 902–910.
Garmyn, M., Mammone, T., Pupe, A., Gan, D., Declercq, L., Maes, D., Human keratinocytes respond to osmotic stress by p38 MAP kinase regulated induction of HSP70 and HSP27. J Invest Dermatol 117 (2001), 1290–1295.
Haftek, M., Epidermal barrier disorders and corneodesmosome defects. Cell Tissue Res 360 (2015), 483–490.
Havlickova, B., Czaika, V.A., Friedrich, M., Epidemiological trends in skin mycoses worldwide. Mycoses 51 (2008), 2–15.
Hayette, M., Sacheli, R., Dermatophytosis, trends in epidemiology and diagnostic approach. Curr Fungal Infect Rep 9 (2015), 164–179.
Heinen, M.P., Cambier, L., Antoine, N., Gabriel, A., Gillet, L., Bureau, F., et al. Th1 and Th17 immune responses act complementary to optimally control superficial dermatophytosis. J Investig Dermatol 139 (2018), 626–637.
Hollox, E.J., Armour, J.A., Barber, J.C., Extensive normal copy number variation of a β–defensin antimicrobial-gene cluster. Am J Hum Genet 73 (2003), 591–600.
Jans, R., Atanasova, G., Jadot, M., Poumay, Y., Cholesterol depletion upregulates involucrin expression in epidermal keratinocytes through activation of p38. J Invest Dermatol 123 (2004), 564–573.
Jaradat, S.W., Cubillos, S., Krieg, N., Lehmann, K., Issa, B., Piehler, S., et al. Low DEFB4 copy number and high systemic hBD-2 and IL-22 levels are associated with dermatophytosis. J Invest Dermatol 135 (2015), 750–758.
Jaradat, S.W., Hoder-Przyrembel, C., Cubillos, S., Krieg, N., Lehmann, K., Piehler, S., et al. Beta-defensin-2 genomic copy number variation and chronic periodontitis. J Dent Res 92 (2013), 1035–1040.
Jayatilake, J.A., Samaranayake, Y.H., Samanarayake, L.P., An ultrastructural and a cytochemical study of candida invasion of reconstituted human oral epithelium. J Oral Pathol Med 34 (2005), 240–246.
Jensen, J.M., Pfeiffer, S., Akaki, T., Schröder, J.M., Kleine, M., Neumann, C., et al. Barrier function, epidermal differentiation, and human β-defensin 2 expression in Tinea corporis. J Invest Dermatol 127 (2007), 1720–1727.
Kirschner, N., Poetzl, C., von den Driesch, P., Wladykowski, E., Moll, I., Behne, M.J., et al. Alteration of tight junction proteins is an early event in psoriasis: putative involvement of proinflammatory cytokines. Am J Pathol 175 (2009), 1095–1106.
Kirschner, N., Rosenthal, R., Furuse, M., Moll, I., Fromm, M., Brandner, J.M., Contribution of tight junction proteins to ion, macromolecule, and water barrier in keratinocytes. J Invest Dermatol 133 (2013), 1161–1169.
Kyriakis, J.M., Avruch, J., Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update. Physiol Rev 92 (2012), 689–737.
Lee, W.J., Kim, S.L., Jang, Y.H., Lee, S.J., Kim, D.W., Bang, Y.J., et al. Increasing prevalence of Trichophyton rubrum identified through an analysis of 115,846 cases over the last 37 years. J Korean Med Sci 30 (2015), 639–643.
Li, M., Chen, Q., Tang, R., Shen, Y., Liu, W.D., The expression of β-defensin-2, 3 and LL-37 induced by Candida albicans phospholipomannan in human keratinocytes. J Dermatol Sci 61 (2011), 72–75.
Martinez-Rossi, N.M., Peres, N.T., Rossi, A., Pathogenesis of dermatophytosis: sensing the host tissue. Mycopathologia 182 (2017), 215–227.
Mathay, C., Giltaire, S., Minner, F., Bera, E., Hérin, M., Poumay, Y., Heparin-binding EGF-like growth factor is induced by disruption of lipid rafts and oxidative stress in keratinocytes and participates in the epidermal response to cutaneous wounds. J Invest Dermatol 128 (2008), 717–727.
Méhul, B., Gu, Z., Jomard, A., Laffet, G., Feuilhade, M., Monod, M., (Tri r 2), an onychomycosis marker revealed by proteomics analysis of Trichophyton rubrum secreted proteins in patient nail samples. J Investig Dermatol 136 (2016), 331–333.
Mignon, B., Tabart, J., Baldo, A., Mathy, A., Losson, B., Vermout, S., Immunization and dermatophytes. Curr Opin Infect Dis 21 (2008), 134–140.
Moyes, D.L., Wilson, D., Richardson, J.P., Mogavero, S., Tang, S.X., Wernecke, J., et al. Candidalysin is a fungal peptide toxin critical for mucosal infection. Nature 532 (2016), 64–68.
Nakamura, Y., Kano, R., Hasegawa, A., Watanabe, S., Interleukin-8 and tumor necrosis factor alpha production in human epidermal keratinocytes induced by Trichophyton mentagrophytes. Clin Diagn Lab Immunol 9 (2002), 935–937.
Netea, M.G., Brown, G.D., Kullberg, B.J., Gow, N.A., An integrated model of the recognition of Candida albicans by the innate immune system. Nat Rev Microbiol 6 (2008), 67–78.
Ohnemus, U., Kohrmeyer, K., Houdek, P., Rohde, H., Wladykowski, E., Vidal, S., et al. Regulation of epidermal tight-junctions (TJ) during infection with exfoliative toxin-negative Staphylococcus strains. J Investig Dermatol 128 (2008), 906–916.
Perera, T.H., Gregory, D.W., Marshall, D., Gow, N.A., Contact-sensing by hyphae of dermatophytic and saprophytic fungi. J Med Vet Mycol 35 (1997), 289–293.
Peus, D., Vasa, R.A., Beyerle, A., Meves, A., Krautmacher, C., Pittelkow, M.R., UVB activates ERK1/2 and p38 signaling pathways via reactive oxygen species in cultured keratinocytes. J Invest Dermatol 112 (1999), 751–756.
Piérard, G.E., Piérard-Franchimont, C., Quatresooz, P., Fungal thigmotropism in onychomycosis and in a clear hydrogel pad model. Dermatology 215 (2007), 107–113.
Proksch, E., Brandner, J.M., Jensen, J.M., The skin: an indispensable barrier. Exp Dermatol 17 (2008), 1063–1072.
Seebacher, C., Bouchara, J.P., Mignon, B., Updates on the epidemiology of dermatophyte infections. Mycopathologia 166 (2008), 335–352.
Shiraki, Y., Ishibashi, Y., Hiruma, M., Nishikawa, A., Ikeda, S., Cytokine secretion profiles of human keratinocytes during Trichophyton tonsurans and Arthroderma benhamiae infections. J Med Microbiol 55 (2006), 1175–1185.
Tabart, J., Baldo, A., Vermout, S., Nusgens, B., Lapiere, C., Losson, B., et al. Reconstructed interfollicular feline epidermis as a model for Microsporum canis dermatophytosis. J Med Microbiol 56 (2007), 971–975.
Tani, K., Adachi, M., Nakamura, Y., Kano, R., Makimura, K., Hasegawa, A., et al. The effect of dermatophytes on cytokine production by human keratinocytes. Arch Dermatol Res 299 (2007), 381–387.
Tran, V.D.T., De Coi, N., Feuermann, M., Schmid-Siegert, E., Băguţ, E.T., Mignon, B., et al. RNA sequencing-based genome reannotation of the dermatophyte Arthroderma benhamiae and characterization of its secretome and whole gene expression profile during infection. mSystems, 1, 2016 00036–16.
van Smeden, J., Bouwstra, J.A., Stratum corneum lipids: their role for the skin barrier function in healthy subjects and atopic dermatitis patients. Curr Probl Dermatol 49 (2016), 8–26.
Vermout, S., Tabart, J., Baldo, A., Mathy, A., Losson, B., Mignon, B., Pathogenesis of dermatophytosis. Mycopathologia 166 (2008), 267–275.
Weitzman, I., Summerbell, R.C., The dermatophytes. Clin Microbiol Rev 8 (1995), 240–259.
Zarubin, T., Han, J., Activation and signaling of the p38 MAP kinase pathway. Cell Res 15 (2005), 11–18.
Zhan, P., Liu, W., The changing face of dermatophytic infections worldwide. Mycopathologia 182 (2017), 77–86.
Zhang, Z., Wang, B., Wu, S., Wen, Y., Wang, X., Song, X., et al. PD169316, a specific p38 inhibitor, shows antiviral activity against Enterovirus71. Virology 508 (2017), 150–158.
