Article (Scientific journals)
Encoding Difficulty Promotes Postlearning Changes in Sleep
Schmidt, Christina; Peigneux, Philippe; Muto, Vincenzo et al.
2006In Journal of Neuroscience, 26 (35), p. 8976-8982
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Keywords :
daytime sleep; sleep spindles; declarative memory
Abstract :
[en] Learning-dependent increases in sleep spindle density have been reported during nocturnal sleep immediately after the learning session. Here, we investigated experience-dependent changes in daytime sleep EEG activity after declarative learning of unrelated word pairs. At weekly intervals, 13 young male volunteers spent three 24 h sessions in the laboratory under carefully controlled homeostatic and circadian conditions. At approximately midday, subjects performed either one of two word-pair learning tasks or a matched nonlearning control task, in a counterbalanced order. The two learning lists differed in the level of concreteness of the words used, resulting in an easier and a more difficult associative encoding condition, as confirmed by performance at immediate cued recall. Subjects were then allowed to sleep for 4 h; afterward, delayed cued recall was tested. Compared with the control condition, sleep EEG spectral activity in the low spindle frequency range and the density of low-frequency sleep spindles (11.25–13.75 Hz) were both significantly increased in the left frontal cortex after the difficult but not after the easy encoding condition. Furthermore, we found positive correlations between theseEEG changes during sleep and changes in memory performance between pre nap and post-nap recall sessions. These results indicate that, like during nocturnal sleep, daytime sleep EEG oscillations including spindle activity are modified after declarative learning of word pairs. Furthermore, we demonstrate here that the nature of the learning material is a determinant factor for sleep-related alterations after declarative learning.
Research center :
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège
Disciplines :
Neurosciences & behavior
Author, co-author :
Schmidt, Christina  ;  Université de Liège - ULiège > Département des sciences cognitives > Neuropsychologie
Peigneux, Philippe ;  Université de Liège - ULiège > Département des sciences cognitives > Département des sciences cognitives
Muto, Vincenzo  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Schenkel, Maya
Knoblauch, Vera
Münch, Mirjam
de Quervain, Dominique J-F
Wirz-Justice, Anna
Cajochen, Christian
Language :
English
Title :
Encoding Difficulty Promotes Postlearning Changes in Sleep
Publication date :
30 August 2006
Journal title :
Journal of Neuroscience
ISSN :
0270-6474
eISSN :
1529-2401
Publisher :
Society for Neuroscience, Washington, United States - District of Columbia
Volume :
26
Issue :
35
Pages :
8976-8982
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
SNSF - Swiss National Science Foundation [CH]
Lundbeck-BCNBP
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
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since 26 September 2009

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