Article (Scientific journals)
Management of Asymptomatic Severe Aortic Stenosis: Evolving Concepts in Timing of Valve Replacement.
Lindman, Brian R.; Dweck, Marc R.; Lancellotti, Patrizio et al.
2019In JACC. Cardiovascular Imaging
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Keywords :
aortic stenosis; biomarkers; cardiac magnetic resonance imaging; echocardiography
Abstract :
[en] New insights into the pathophysiology and natural history of patients with aortic stenosis, coupled with advances in diagnostic imaging and the dramatic evolution of transcatheter aortic valve replacement, are fueling intense interest in the management of asymptomatic patients with severe aortic stenosis. An intervention that is less invasive than surgery could conceivably justify pre-emptive transcatheter aortic valve replacement in subsets of patients, rather than waiting for the emergence of early symptoms to trigger valve intervention. Clinical experience has shown that symptoms can be challenging to ascertain in many sedentary, deconditioned, and/or elderly patients. Evolving data based on imaging and biomarker evidence of adverse ventricular remodeling, hypertrophy, inflammation, or fibrosis may radically transform existing clinical decision paradigms. Clinical trials currently enrolling asymptomatic patients have the potential to change practice patterns and lower the threshold for intervention.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Lindman, Brian R.
Dweck, Marc R.
Lancellotti, Patrizio  ;  Université de Liège - ULiège > Département des sciences cliniques > Cardiologie - Pathologie spéciale et réhabilitation
Genereux, Philippe
Pierard, Luc ;  Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
O'Gara, Patrick T.
Bonow, Robert O.
Language :
English
Title :
Management of Asymptomatic Severe Aortic Stenosis: Evolving Concepts in Timing of Valve Replacement.
Publication date :
2019
Journal title :
JACC. Cardiovascular Imaging
ISSN :
1936-878X
eISSN :
1876-7591
Publisher :
Elsevier, Netherlands
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Copyright (c) 2019 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
Available on ORBi :
since 05 September 2019

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