Unpublished conference/Abstract (Scientific congresses and symposiums)
Greater preserved baseline functional MRI connectivity in zolpidem responders compared to non-responders in patients with disorders of consciousness.
Ippoliti, Camilla; Larroque, Stephen Karl; Sanz, Leandro et al.
2019Congress of the European Academy of Neurology
Peer reviewed
 

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Abstract :
[en] Introduction Zolpidem is commonly used as sleep inducer but is one of the few available pharmacological treatments for patients with disorders of consciousness (DOC). Some DOC patients have exhibited paradoxical improvements with zolpidem treatment but the neurological profile of responders remains unclear. No fMRI study has ever been conducted in a group of DOC patients. We investigated the baseline functional brain connectivity in DOC patients responding to zolpidem compared to non-responding patients. Methods Eleven patients in minimally conscious state and 5 who emerged received a 10 mg single dose of zolpidem. Patients were considered responders if a new behaviour was observed using the Coma Recovery Scale-Revised after zolpidem administration. All patients underwent resting-state fMRI (without zolpidem). Hypothesis-free and seed-based region (thalamus) analyses were conducted with age and gender covariates regressed out, comparing patients with 36 healthy volunteers. Results Seven patients qualified as responders (5 sedated, 2 non-sedated) and 9 as non-responders (6 sedated, 3 non-sedated). Hypothesis-free analyses in the sedated group revealed significantly increased intrinsic connectivity among responders in the occipital, occipito-temporal and parieto-occipital areas compared to non-responders. Seed-based analyses showed significantly more preserved positive connectivity of the fronto-insular network in responders compared to non-responders. No significant differences were found between responders and non-responders in the non-sedated condition, possibly due to smaller sample size. Conclusion Our findings suggest a greater preservation of global and local connectivity in zolpidem responders at baseline. Targeting more accurately potential responders to zolpidem can improve the clinical management of DOC patients.
Research Center/Unit :
Coma Science Group - GIGA Consciousness
Disciplines :
Neurology
Author, co-author :
Ippoliti, Camilla ;  Université de Liège - ULiège > Consciousness-Coma Science Group
Larroque, Stephen Karl  ;  Université de Liège - ULiège > Consciousness-Coma Science Group
Sanz, Leandro  ;  Université de Liège - ULiège > Consciousness-Coma Science Group
Bahri, Mohamed Ali  ;  Université de Liège - ULiège > CRC In vivo Imaging-Aging & Memory
Carrière, Manon ;  Université de Liège - ULiège > Consciousness-Coma Science Group
Aubinet, Charlène  ;  Université de Liège - ULiège > Consciousness-Coma Science Group
Martial, Charlotte  ;  Université de Liège - ULiège > Consciousness-Coma Science Group
Heine, Lizette 
Charland-Verville, Vanessa ;  Université de Liège - ULiège > Consciousness-Coma Science Group
VANHAUDENHUYSE, Audrey  ;  Centre Hospitalier Universitaire de Liège - CHU > Département d'Anesthésie et réanimation > Centre interdisciplinaire d'algologie
Di Perri, Carol ;  Université de Liège - ULiège > Consciousness-Coma Science Group
Laureys, Steven  ;  Université de Liège - ULiège > Consciousness-Coma Science Group
Gosseries, Olivia  ;  Université de Liège - ULiège > Consciousness-Coma Science Group
More authors (3 more) Less
Language :
English
Title :
Greater preserved baseline functional MRI connectivity in zolpidem responders compared to non-responders in patients with disorders of consciousness.
Publication date :
30 June 2019
Event name :
Congress of the European Academy of Neurology
Event organizer :
European Academy of Neurology
Event place :
Oslo, Norway
Event date :
29 juin au 2 juillet
Audience :
International
Peer reviewed :
Peer reviewed
References of the abstract :
C. Ippoliti, SK. Larroque, LRD. Sanz, MA. Bahri, M. Carrière, C. Aubinet, C. Martial, L. Heine, V. Charland-Verville, A. Vanhaudenhuyse, C. Di Perri, S. Laureys, O. Gosseries, “Greater preserved baseline functional MRI connectivity in zolpidem responders compared to non-responders in patients with disorders of consciousness”, Abstracts of the 5th Congress of the European Academy of Neurology, Oslo, Norway, ePresentation Sessions. Eur J Neurol, 26:S1, 112-346. doi:10.1111/ene.14018
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique
Commentary :
DOI du volume d'abstract: 10.1111/ene.14018
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since 29 August 2019

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