Adolescent; Adult; Attention/physiology; Brain/physiology; Cognition/physiology; Female; Humans; Male; Memory, Short-Term/physiology; Neuronal Plasticity; Synapses/physiology; Transcranial Magnetic Stimulation; Young Adult
Abstract :
[en] The ability to hold information in working memory is fundamental for cognition. Contrary to the long-standing view that working memory depends on sustained, elevated activity, we present evidence suggesting that humans can hold information in working memory via "activity-silent" synaptic mechanisms. Using multivariate pattern analyses to decode brain activity patterns, we found that the active representation of an item in working memory drops to baseline when attention shifts away. A targeted pulse of transcranial magnetic stimulation produced a brief reemergence of the item in concurrently measured brain activity. This reactivation effect occurred and influenced memory performance only when the item was potentially relevant later in the trial, which suggests that the representation is dynamic and modifiable via cognitive control. The results support a synaptic theory of working memory.
Disciplines :
Neurosciences & behavior
Author, co-author :
Rose, Nathan S.
LaRocque, Joshua J.
Riggall, Adam C.
Gosseries, Olivia ; Université de Liège - ULiège > Centre de recherches du cyclotron
Starrett, Michael J.
Meyering, Emma E.
Postle, Bradley R.
Language :
English
Title :
Reactivation of latent working memories with transcranial magnetic stimulation.
Publication date :
2016
Journal title :
Science
ISSN :
0036-8075
eISSN :
1095-9203
Publisher :
American Association for the Advancement of Science, Washington, United States - District of Columbia
Volume :
354
Issue :
6316
Pages :
1136-1139
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Copyright (c) 2016, American Association for the Advancement of Science.
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