Article (Scientific journals)
Clinical performance of a specific granulocyte colony stimulating factor ELISA to determine its concentration in follicular fluid as a predictor of implantation success during in vitro fertilization.
Tournaye, H; D'Hooghe, T.; Verheyen, G. et al.
2019In Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, p. 1-5
Peer reviewed
 

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Keywords :
fertilization; Granulocyte colony stimulating factor; embryo selection
Abstract :
[en] This study aimed to demonstrate the clinical performance of an ultra-sensitive follicular fluid (FF) granulocyte colony stimulating factor (G-CSF) immunoassay to confirm previous work, indicating a correlation between FF G-CSF concentration and live birth potential of the corresponding embryo after in vitro fertilization. This study was a noninterventional, prospective, diagnostic clinical multicentric study conducted between August 2012 and January 2014 with 396 single embryo transfers (SETs) from 278 subjects. During oocyte retrieval, FF was individually collected. Embryo morphology and implantation success were evaluated. The implantation success rate in the high G-CSF group (32.3%) was higher than the overall rate (27.5%). Similarly, for embryos with optimal morphology, implantation success rates were highest among those in the high G-CSF concentration category (34.5%) compared with low (19.6%) and intermediate (29.8%) G-CSF concentration categories. Significant differences in mean G-CSF concentrations were observed between the study sites. To minimize bias, analyses were repeated using data from the center with the largest number of SETs. In alignment with the overall analysis, this center demonstrated a 43% greater probability of implantation for optimal embryos with high G-CSF compared to the general implantation rate among optimal embryos and a 327% increase compared with the implantation rate of optimal embryos with low G-CSF.
Disciplines :
Reproductive medicine (gynecology, andrology, obstetrics)
Author, co-author :
Tournaye, H
D'Hooghe, T.
Verheyen, G.
Devreker, K. F.
PERRIER d'HAUTERIVE, Sophie ;  Centre Hospitalier Universitaire de Liège - CHU > Département de gynécologie-obstétrique > Centre de procréation médicalement assistée (CPMA)
Nisolle, Michelle ;  Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique
Foidart, Jean-Michel ;  Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
Munaut, Carine  ;  Université de Liège - ULiège > Cancer-Tumours and development biology
NOEL, Laure ;  Centre Hospitalier Universitaire de Liège - CHU > Département de gynécologie-obstétrique > Service de gynécologie-obstétrique (CHR)
Language :
English
Title :
Clinical performance of a specific granulocyte colony stimulating factor ELISA to determine its concentration in follicular fluid as a predictor of implantation success during in vitro fertilization.
Publication date :
June 2019
Journal title :
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
ISSN :
0951-3590
eISSN :
1473-0766
Pages :
1-5
Peer reviewed :
Peer reviewed
Available on ORBi :
since 27 June 2019

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