Methyl-β-cyclodextrin concurs with interleukin (IL)-4, IL-13 and IL-25 to induce altercations reminiscent of atopic dermatitis in reconstructed human epidermis
De Vuyst, Evelyne; Giltaire, Séverine; Lambert de Rouvroit, Catherineet al.
Methyl-B-cyclodextrin concurs with interkeukin (IL)-4,-IL-13 and IL-25 to induce alterations reminiscent of atopic dermatitis in reconstructed human epidermis.pdf
atopic dermatitis; reconstructed human epidermis,; interleukins; methylbeta-cyclodextrin; epidermal barrier
Abstract :
[en] Reconstructed human epidermis (RHE) mimic normal human in vivo epidermis in terms of histology,
distribution of differentiation markers, and barrier functionality (1).
A typical transcriptional profile and the activation of signalling pathways reminiscent of atopic
dermatitis (AD) lesional skin can be obtained in RHE upon incubation with methyl-β-cyclodextrin
(MβCD) (2, 3), a molecule that extracts cholesterol from plasma membranes, thereby disrupting lipid microdomains. However, barrier function and morphology remain unaltered in those conditions, requiring further refinement of the model.
Disciplines :
Dermatology
Author, co-author :
De Vuyst, Evelyne; University of Namur > URPhyM-NARILIS
Giltaire, Séverine; University of Namur > URPhyM-NARILIS
Lambert de Rouvroit, Catherine; University of Namur > URPhyM-NARILIS
Malaisse, Jérémy; University of Namur > URPhyM-NARILIS
Mound, Abdallah; University of Namur > URPhyM-NARILIS
Bourtembourg, Maureen; University of Namur > URPhyM-NARILIS
Poumay, Yves; University of Namur > URPhyM-NARILIS
NIKKELS, Arjen ; Centre Hospitalier Universitaire de Liège - CHU > Autres Services Médicaux > Service de dermatologie
CHRETIEN, Aline; StratiCell > Les Isnes, Belgium
Salmon, Michel; StratiCell > Les Isnes, Belgium
Language :
English
Title :
Methyl-β-cyclodextrin concurs with interleukin (IL)-4, IL-13 and IL-25 to induce altercations reminiscent of atopic dermatitis in reconstructed human epidermis
