Cortical reactivations during sleep spindles following declarative learning

[en] Increasing evidence suggests that sleep spindles are involved in memory consolidation, but few studies have investigated the effects of learning on brain responses associated with spindles in humans. Here we used simultaneous electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) during sleep to assess haemodynamic brain responses related to spindles after learning. Twenty young healthy participants were scanned with EEG/fMRI during (i) a declarative memory face sequence learning task, (ii) subsequent sleep, and (iii) recall after sleep (learning night). As a control condition an identical EEG/fMRI scanning protocol was performed after participants over-learned the face sequence task to complete mastery (control night). Results demonstrated increased responses in the fusiform gyrus both during encoding before sleep and during successful recall after sleep, in the learning night compared to the control night. During sleep, a larger response in the fusiform gyrus was observed in the presence of fast spindles during the learning as compared to the control night. Our findings support a cortical reactivation during fast spindles of brain regions previously involved in declarative learning and subsequently activated during memory recall, thereby promoting the cortical consolidation of memory traces. © 2019 Elsevier Inc.

Disciplines :

Neurology

Author, co-author :

Jegou, A.; PERFORM Center, Concordia University, 7200 Sherbrooke St W, Montreal, H4B 1R6, Canada, Department of Physics, Concordia University, 7141 Sherbrooke St W, Montreal, H4B 1R6, Canada, Center for Studies in Behavioral Neurobiology (CSBN), Concordia University, 7141 Sherbrooke St W, Montreal, H4B 1R6, Canada

Schabus, M.; Center for Cognitive Neuroscience (CCNS), Department of Psychology, University of Salzburg, 34 Hellbrunnerstr., Salzburg, 5020, Austria

Gosseries, Olivia ; Université de Liège - ULiège > Consciousness-Coma Science Group

Dahmen, B.; Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, RWTH Aachen University, Neuenhofer Weg 21, Aachen, 52074, Germany

Albouy, G.; Department of Movement Sciences, KU Leuven, 101 Tervuursevest, Leuven, 3001, Belgium

Desseilles, Martin ; Université de Liège - ULiège > GIGA CRC In vivo Imaging

Sterpenich, V.; Department of Neuroscience, University Medical Center, 9 Chemin des Mines, Geneva, 1202, Switzerland

Phillips, Christophe ; Université de Liège - ULiège > CRC In vivo Im.-Neuroimaging, data acquisition & processing

Maquet, Pierre ; Université de Liège - ULiège > Département des sciences cliniques > Neurologie

Grova, C.; PERFORM Center, Concordia University, 7200 Sherbrooke St W, Montreal, H4B 1R6, Canada, Department of Physics, Concordia University, 7141 Sherbrooke St W, Montreal, H4B 1R6, Canada, Department of Biomedical Engineering, McGill University, 3801 University St, Montreal, H3A 2B4, Canada, Department of Neurology and Neurosurgery, McGill University, 3801 University St, Montreal, H3A 2B4, Canada

Dang-Vu, T. T.; PERFORM Center, Concordia University, 7200 Sherbrooke St W, Montreal, H4B 1R6, Canada, Center for Studies in Behavioral Neurobiology (CSBN), Concordia University, 7141 Sherbrooke St W, Montreal, H4B 1R6, Canada, Department of Health, Kinesiology and Applied Physiology, Concordia University, 7141 Sherbrooke St W, Montreal, H4B 1R6, Canada, Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal (CRIUGM), 4545 Chemin Queen-Mary, M7834, Montreal, H3W 1W5, Canada

Language :

English

Title :

Cortical reactivations during sleep spindles following declarative learning

Publication date :

2019

Journal title :

NeuroImage

ISSN :

1053-8119

eISSN :

1095-9572

Publisher :

Academic Press Inc.

Volume :

195

Pages :

104-112

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 14 June 2019

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