Article (Scientific journals)
Experimental measurements validate the use of the binary encounter approximation model to accurately compute proton induced dose and radiolysis enhancement from gold nanoparticles
Hespeels, Félicien; Lucas, Stephane; Tabarrant, Tijani et al.
2019In Physics in Medicine and Biology, 64 (6)
Peer Reviewed verified by ORBi
 

Files


Full Text
Hespeels_2019_Phys._Med._Biol._64_065014.pdf
Publisher postprint (6.41 MB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Electron energy levels; Geant4; Gold nanoparticles
Abstract :
[en] In protontherapy, it has been suggested that nanoparticles of high-Z material like gold (GNP) could be used as radiosensitizers. The origin of this enhancement phenomenon for proton radiation is not yet well understood and additional mechanistic insights are required. Previous works have highlighted the good capabilities of TRAX to reproduce secondary electron emission from gold material. Therefore, TRAX cross sections obtained with the binary encounter approximation (BEA) model for proton ionization were implemented within Geant4 for gold material. Based on the TRAX cross sections, improved Geant4 simulations have been developed to investigate the energy deposition and radical species production around a spherical gold nanoparticle (5 and 10 nm in diameter) placed in a water volume during proton irradiation. Simulations were performed for incident 2 MeV proton. The dose enhancement factor and the radiolysis enhancement factor were quantified. Results obtained with the BEA model were compared with results obtained with condensed-history models. Experimental irradiation of 200 nm gold films were performed to validate the secondary electron emission reproduction capabilities of physical models used in Monte Carlo (MC) simulations. TRAX simulations reproduced the experimental backscattered electron energy spectrum from gold film with better agreement than Geant4. Results on gold film obtained with the BEA model enabled to estimate the electron emission from GNPs. Results obtained in our study tend to support that the use of the BEA discrete model leads to a significant increase of the dose in the near vicinity of GNPs (<20 nm), while condensed history models used in Geant4 seem to overestimate the dose and the number of chemical species for increasing distances from the GNP. Based on discrete BEA model results, no enhancement effect due to secondary electron emitted from the GNP is expected if the GNP is not in close proximity to key cellular functional elements (DNA, mitochondria...). © 2019 Institute of Physics and Engineering in Medicine.
Research center :
AAP - Art, Archéologie et Patrimoine - ULiège
Disciplines :
Physical, chemical, mathematical & earth Sciences: Multidisciplinary, general & others
Author, co-author :
Hespeels, Félicien;  University of Namur, PMR, 61 rue de Bruxelles, Namur, 5000, Belgium
Lucas, Stephane;  TIFPA-INFN, Trento Institute for Fundamental Physics and Applications, via Sommarive 14, Trento, I-38123, Italy
Tabarrant, Tijani;  GSI- Helmholtzzentrum für Schwerionenforschung Biophysik, Max Planck-Strasse 1, Darmstadt, D-64291, Germany
Scifoni, Emanuele;  Institut de Physique Nucleaire, Atomique et Spectroscopie, Centre Europeen d'Archeometrie, Université de Liège, Sart Tilman B15, Liege, B-4000, Belgium
Kraemer, Michael;  Division of Nuclear Physics, Advanced Institute of Materials Science, Ton Duc Thang University, Ho Chi Minh City, Viet Nam
Chene, Grégoire ;  Université de Liège - ULiège > Département de physique > Spectroscopie atomique et nucléaire, archéométrie
Strivay, David  ;  Université de Liège - ULiège > Département de physique > Spectroscopie atomique et nucléaire, archéométrie
Tran, Hoang Son ;  Université de Liège - ULiège > Département ArGEnCo > Département Argenco : Secteur MS2F
Heuskin, Anne-Catherine
Language :
English
Title :
Experimental measurements validate the use of the binary encounter approximation model to accurately compute proton induced dose and radiolysis enhancement from gold nanoparticles
Publication date :
2019
Journal title :
Physics in Medicine and Biology
ISSN :
0031-9155
eISSN :
1361-6560
Publisher :
Institute of Physics Publishing
Volume :
64
Issue :
6
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 06 June 2019

Statistics


Number of views
69 (10 by ULiège)
Number of downloads
5 (5 by ULiège)

Scopus citations®
 
14
Scopus citations®
without self-citations
9
OpenCitations
 
8

Bibliography


Similar publications



Contact ORBi