Article (Scientific journals)
Use of vaccinia rabies recombinant for oral vaccination of wildlife
Desmettre, P.; Languet, B.; Chappuis, G. et al.
1990In Veterinary Microbiology, 23 (1-4), p. 227-236
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Keywords :
Animal; Animals, Wild; Disease Vectors; Rabies; Rabies Vaccines; Vaccination; Vaccines, Synthetic; Vaccinia virus; Animalia; Bos taurus; Canis familiaris; Cavia porcellus; Cricetinae; Felis catus; Oryctolagus cuniculus; Ovis aries; Sus scrofa; Vaccinia
Abstract :
[en] A vaccinia rabies recombinant virus was contructed and shown to induce the synthesis of rabies virus glycoprotein in infected cells and to induce rabies virus neutralizing antibodies and protection in susceptible animals. Active when orally administered, this recombinant is a good candidate for the development of vaccines for wild animal rabies vectors. This recombinant was found stable, safe for target and non-target animal species, and protective for most of the rabies vectors. After extensive experimental studies conducted under controlled conditions, it as used in limited field trials and in an extensive open field trial. The preliminary results confirmed its basic properties and potential for rabies eradication. © 1990.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Desmettre, P.;  Rhône-Mérieux > Laboratoire IFFA
Languet, B.;  Rhône-Mérieux > Laboratoire IFFA
Chappuis, G.;  Rhône-Mérieux > Laboratoire IFFA
Brochier, B.;  Université de Liège - ULiège > Faculté de Médecine vétérinaire
Thomas, I.;  Université de Liège - ULiège > Faculté de Médecine vétérinaire
Lecocq, J.-P.;  Transgene S.A. (France)
Kieny, M.-P.;  Transgene S.A. (France)
Blancou, J.;  Centre National d'Etudes Vétérinaires et Alimentaires (France)
Aubert, M.;  Centre National d'Etudes Vétérinaires et Alimentaires (France)
Artois, M.;  Rhône-Mérieux > Laboratoire IFFA
Pastoret, Paul-Pierre ;  Université de Liège - ULiège > Faculté de Médecine vétérinaire
Language :
English
Title :
Use of vaccinia rabies recombinant for oral vaccination of wildlife
Publication date :
1990
Journal title :
Veterinary Microbiology
ISSN :
0378-1135
eISSN :
1873-2542
Publisher :
Elsevier Science, Amsterdam, Netherlands
Volume :
23
Issue :
1-4
Pages :
227-236
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 01 June 2019

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