Article (Scientific journals)
Skeletal deformities induced by the intraperitoneal administration of deoxynivalenol (vomitoxin) in mice
Debouck, C.; Haubruge, Eric; Bollaerts, P. et al.
2001In International Orthopaedics, 25 (3), p. 194-198
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Keywords :
Kashin-Beck disease; mycotoxin
Abstract :
[en] The contamination of drinking water by organic acids, selenium deficiency and the ingestion of fungal mycotoxins are the three main aetiological factors in the development of Kashin-Beck disease. An avian tibial chondrodysplasia induced by mycotoxins has been reported. Deoxynivalenol (DON) is one of many mycotoxins produced by the most common contaminating species of fungi. The pattern of skeletal malformations induced by its administration intraperitoneally to pregnant mice is reported. Costo-vertebral segmentation abnormalities were the main deformities observed. The chondrodysplasia previously described was not seen.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Debouck, C.
Haubruge, Eric  ;  Université de Liège - ULiège > Gembloux Agro-Bio Tech > Gembloux Agro-Bio Tech
Bollaerts, P.
van Bignoot, D.
Brostaux, Yves  ;  Université de Liège - ULiège > Gembloux Agro-Bio Tech > Gembloux Agro-Bio Tech
Werry, A.
Rooze, M.
Language :
English
Title :
Skeletal deformities induced by the intraperitoneal administration of deoxynivalenol (vomitoxin) in mice
Publication date :
2001
Journal title :
International Orthopaedics
ISSN :
0341-2695
eISSN :
1432-5195
Publisher :
Springer Verlag, Berlin, Germany
Volume :
25
Issue :
3
Pages :
194-198
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 24 September 2009

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