Article (Scientific journals)
Effects of Natural Products on Mcl-1 Expression and Function.
Muller, Florian; Cerella, Claudia; Radogna, Flavia et al.
2015In Current Medicinal Chemistry, 22 (30), p. 3447-61
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Keywords :
Biological Products/pharmacology; Cardenolides/chemistry/pharmacology; Drug Delivery Systems; Gene Expression Regulation, Neoplastic/drug effects; Humans; Molecular Structure; Myeloid Cell Leukemia Sequence 1 Protein/genetics/metabolism; Neoplasms/drug therapy; Proto-Oncogene Proteins c-bcl-2/metabolism
Abstract :
[en] Cancer development is mostly due to a deregulation of cell death as cancer cells become resistant to apoptosis by increasing expression of anti-apoptotic proteins belonging to the Bcl-2 family. Mcl-1 is one anti-apoptotic protein, which is mainly responsible for cancer cell resistance as it is overexpressed by most cancer cell types. Many research projects aim to restore cancer cell death by using natural pharmacological scaffolds targeting anti-apoptotic proteins to inhibit their effect in cancer development. This review introduces natural compound inhibitors of the Bcl-2 protein family with a focus on Mcl-1.
Disciplines :
Anatomy (cytology, histology, embryology...) & physiology
Author, co-author :
Muller, Florian ;  Université de Liège - ULiège > Cancer-Molecular Angiogenesis Laboratory
Cerella, Claudia
Radogna, Flavia
Dicato, Mario
Diederich, Marc
Language :
English
Title :
Effects of Natural Products on Mcl-1 Expression and Function.
Publication date :
2015
Journal title :
Current Medicinal Chemistry
ISSN :
0929-8673
eISSN :
1875-533X
Publisher :
Bentham Science Publishers, Schiphol, Netherlands
Volume :
22
Issue :
30
Pages :
3447-61
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 28 May 2019

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