Gel-free proteomics

[en] Mass spectrometry (MS)-based proteomics is nowadays considered as a mainstream analytical tool for life sciences. This success is mainly to be attributed to the tremendous improvements in the core technology of mass spectrometry coupled with recent developments in bioinformatics and separation sciences. The level of information that is henceforth accessible through MS techniques is broad and encompasses the protein sequence as well as its quantity, modification(s), structure, and implication in macromolecular assemblies. The current chapter focuses on the existing gel-free MS-based quantitative approaches that are applicable in the field of animal sciences and summarizes their principal features together with their respective advantages and drawbacks. In this context, we will discuss both the label-free and label-based relative quantitation strategies as well as the existing alternatives for absolute quantitation. The specific case of posttranslational modifications, whose extensive characterization is becoming a crucial topic in MS-based proteome studies, is next addressed under the quantitative scope of phosphorylation and glycosylation. Lastly, other promising nonmainstream techniques are presented, emphasizing their potent use to solve major proteomics challenges of tomorrow. © Springer International Publishing AG 2018. All rights reserved.

Disciplines :

Chemistry

Author, co-author :

Baiwir, Dominique ; Université de Liège - ULiège > GIGA-Technology platforms : Plate-forme protéomique

Nanni, P.; Functional Genomics Center Zurich, University/ETH Zurich, Zurich, Switzerland

Müller, S.; Biognosys AG, Schlieren, Switzerland

Smargiasso, Nicolas ; Université de Liège - ULiège > Département de chimie (sciences) > Laboratoire de spectrométrie de masse (L.S.M.)

Morsa, Denis ; Université de Liège - ULiège > Département de chimie (sciences) > Center for Analytical Research and Technology (CART)

De Pauw, Edwin ; Université de Liège - ULiège > Département de chimie (sciences) > Laboratoire de spectrométrie de masse (L.S.M.)

Mazzucchelli, Gabriel ; Université de Liège - ULiège > Département de chimie (sciences) > Laboratoire de spectrométrie de masse (L.S.M.)

Language :

English

Title :

Gel-free proteomics

Publication date :

2018

Main work title :

Proteomics in Domestic Ani-mals: from Farm to Systems Biology

Editor :

de Almeida, Andre Martinho

Eckersal, David

Miller, Ingrid

Publisher :

Springer, Cham

ISBN/EAN :

978-3-319-69681-2

Peer reviewed :

Peer reviewed

Commentary :

9783319696829; 9783319696812

Available on ORBi :

since 24 May 2019

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81 (9 by ULiège)

Number of downloads

3 (2 by ULiège)

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