Poster (Scientific congresses and symposiums)
Metabolic reprogramming of human monocytes/macrophages in obesity ; implications in obesity-linked inflammation and cancers.
Iovino, Margaud; Paquot, Nicolas; Legrand, Sylvie
2019PhD Day 2019
 

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Keywords :
Obesity; Inflammation; Metabolism
Abstract :
[en] Obesity is an ongoing worldwide epidemic now recognized as a low-grade inflammatory disease, favoring the development of metabolic diseases and cancers. This systemic inflammation results mainly from an excessive accumulation of M1-polarized macrophages in adipose tissue. Chronic, low-grade inflammation has long been associated with cancer initiation, promotion and progression. Free fatty acids (FFAs) concentrations are strongly increased in adipose tissue and in the blood of obese patients. Since saturated fatty acids, unlike unsaturated ones, were shown to induce pro-inflammatory pathways, they are suspected of triggering this M1 macrophage polarization.
Disciplines :
Immunology & infectious disease
Author, co-author :
Iovino, Margaud ;  Université de Liège - ULiège > I3-Immunometabolism and Nutrition
Paquot, Nicolas ;  Université de Liège - ULiège > Département des sciences de la santé publique > Diabétologie, nutrition et maladies métaboliques
Legrand, Sylvie ;  Université de Liège - ULiège > I3-Immunometabolism and Nutrition
Language :
English
Title :
Metabolic reprogramming of human monocytes/macrophages in obesity ; implications in obesity-linked inflammation and cancers.
Publication date :
May 2019
Event name :
PhD Day 2019
Event date :
17-05-2019
Available on ORBi :
since 24 May 2019

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