Article (Scientific journals)
Oral vaccination of the fox against rabies using a live recombinant vaccinia virus.
Blancou, J.; Kieny, M. P.; Lathe, R. et al.
1986In Nature, 322 (6077), p. 373-5
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Keywords :
Administration, Oral; Animals; Animals, Wild; Antigens, Surface/genetics/immunology; Antigens, Viral/genetics/immunology; Female; Foxes; Injections, Intradermal; Injections, Subcutaneous; Male; Neutralization Tests; Rabies/prevention & control/transmission/veterinary; Rabies Vaccines/administration & dosage/isolation & purification; Recombination, Genetic; Vaccinia virus/genetics
Abstract :
[en] Rabies, a viral disease affecting all warm-blooded animals, is prevalent in most parts of the world, where it propagates amongst wild animals, particularly the fox and dog. The public health and economic consequences of infection in man and livestock are well known. Attempts to control the disease by vaccinating wild carnivores with inactivated or attenuated rabies virus remain controversial, and we have instead evaluated here the potential of a recombinant vaccinia virus to protect foxes against the disease. We have found that the administration of vaccinia virus (VV) or a recombinant harbouring the rabies surface antigen gene (VVTGgRAB) is innocuous to foxes. The recombinant virus can elicit the production of titers of rabies-neutralizing antibodies equal or superior to those obtained with conventional vaccine, and 10(8) plaque-forming units (PFU) of VVTGgRAB administered subcutaneously, intradermally or orally confers complete protection to severe challenge infection with street rabies virus.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Blancou, J.;  Ministère de l'Agriculture, Malzeville, France
Kieny, M. P.;  Transgène, Strasbourg, France
Lathe, R.;  Transgène, Strasbourg, France
Lecocq, J. P.;  Transgène, Strasbourg, France
Pastoret, Paul-Pierre ;  Université de Liège - ULiège > Faculté de Médecine vétérinaire
Soulebot, J. P.;  Rhône-Mérieux, Lyon, France
Desmettre, P.;  Rhône-Mérieux, Lyon, France
Language :
English
Title :
Oral vaccination of the fox against rabies using a live recombinant vaccinia virus.
Publication date :
1986
Journal title :
Nature
ISSN :
0028-0836
eISSN :
1476-4687
Publisher :
Nature Publishing Group, London, United Kingdom
Volume :
322
Issue :
6077
Pages :
373-5
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 21 May 2019

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