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Article (Scientific journals)
Protection of cattle from infection with vaccinia virus by bovine interferon alpha C.
Schwers, A.; Severin, J. E.; Bublot, M. et al.
1989 • In Veterinary Record, 125 (1), p. 15-6
Peer Reviewed verified by ORBi
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https://hdl.handle.net/2268/235707
DOI
10.1136/vr.125.1.15
PubMed
2781688
 

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Keywords :
2',5'-Oligoadenylate Synthetase/biosynthesis; Animals; Cattle; Cattle Diseases/prevention & control; Enzyme Induction; Interferon Type I/pharmacokinetics/therapeutic use; Lymphocytes/enzymology; Recombinant Proteins; Vaccinia/prevention & control/veterinary
Abstract :
[en] The efficacy of bovine interferon alpha C as an antiviral compound was evaluated in calves infected with vaccinia virus. Calves treated with the interferon did not develop characteristic vaccinia lesions, demonstrating a clear protective effect of treatment. The only side effect observed was hyperthermia. After intramuscular injection, interferon appeared quickly in the blood and was cleared within 24 hours. The in vivo antiviral activity of bovine interferon alpha C was confirmed by its ability to induce 2'5' A synthetase, an enzyme implicated in the antiviral state, in lymphocytes.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Schwers, A.;  Université de Liège - ULiège > Faculté de Médecine vétérinaire
Severin, J. E.;  Faculty of Sciences, Université Libre de Bruxelles, Belgium
Bublot, M.;  Université de Liège - ULiège > Faculté de Médecine vétérinaire
Maenhoudt, M.;  Université de Liège - ULiège > Faculté de Médecine vétérinaire
Pastoret, Paul-Pierre ;  Université de Liège - ULiège > Faculté de Médecine vétérinaire
Vanden Broecke, C.;  Faculty of Sciences, Université Libre de Bruxelles, Belgium
Zilimwabagabo, P.;  Faculty of Sciences, Université Libre de Bruxelles, Belgium
Velan, B.;  Department of Biochemistry, Israël Institute for Biological Research, Ness-Ziona, Israël
Cohen, S.;  Department of Biochemistry, Israël Institute for Biological Research, Ness-Ziona, Israël
Shafferman, A.;  Israel Instutute for biological research, Biochemistry, Ness-Ziona, Israel
Werenne, J.J.;  Université Libre de Bruxelles - ULB
Language :
English
Title :
Protection of cattle from infection with vaccinia virus by bovine interferon alpha C.
Publication date :
1989
Journal title :
Veterinary Record
ISSN :
0042-4900
eISSN :
2042-7670
Publisher :
British Veterinary Association, United Kingdom
Volume :
125
Issue :
1
Pages :
15-6
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 21 May 2019

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