Article (Scientific journals)
Nomenclature internationale des differents types d'anticorps monoclonaux.
Scheen, André
2009In Revue Médicale de Liège, 64 (5-6), p. 244-7
Peer reviewed
 

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Keywords :
Animals; Antibodies, Monoclonal/chemistry/classification; Humans
Abstract :
[en] Significant advances in the development of monoclonal antibodies ("mabs") have been acknowledged during the last two decades. Successive developments led to the marketing of murine antibodies ("o-mab" first, followed by chimeric antibodies ("xi-mab"), humanised antibodies ("zu-mab") and, finally, human monoclonal antibodies ("u-mab"). In order to facilitate the distinction between the various monoclonal antibodies used in clinical practice, an international nomenclature has been proposed with the use of a specific suffix corresponding to the origine/source of "mabs" preceded by an infix referring to the medicine's target. The efforts in developing new types of monoclonal antibodies aimed at improving their pharmacokinetics (longer half-life), pharmacodynamics (better efficacy because of stronger affinity to human receptor), and safety profile (less antigenic and immunogenic reactions). These progresses could be obtained thanks to the remarkable development of molecular biotechnology.
Disciplines :
Immunology & infectious disease
Author, co-author :
Scheen, André  ;  Université de Liège - ULiège > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques - Médecine interne générale
Language :
French
Title :
Nomenclature internationale des differents types d'anticorps monoclonaux.
Alternative titles :
[en] International classification of various types of monoclonal antibodies
Publication date :
2009
Journal title :
Revue Médicale de Liège
ISSN :
0370-629X
eISSN :
2566-1566
Publisher :
Hopital de Baviere, Liège, Belgium
Volume :
64
Issue :
5-6
Pages :
244-7
Peer reviewed :
Peer reviewed
Additional URL :
Available on ORBi :
since 24 September 2009

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