[en] In this communication, we will report the development of a capillary electrophoresis approach for the screening of fragments towards thrombin and FXIIa. We performed direct and competitive ACE-binding assays for the screening of molecules at physiological pH.
Research Center/Unit :
CIRM - Centre Interdisciplinaire de Recherche sur le Médicament - ULiège NAmur Research Institute for Life - NARILIS
Disciplines :
Pharmacy, pharmacology & toxicology Chemistry
Author, co-author :
Davoine, Clara ; Université de Liège - ULiège > Doct. sc. bioméd. & pharma. (paysage)
Farcas, Elena ; Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments
Bouckaert, Charlotte; Université de Namur - UNamur > Département de pharmacie > Namur Medicine & Drug Innovation Center (NAMEDIC – NARILIS)
Pochet, Lionel; Université de Namur - UNamur > Département de pharmacie > Namur Medicine & Drug Innovation Center (NAMEDIC – NARILIS)
Fillet, Marianne ; Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments
Language :
English
Title :
Development of fragments screening bioassays towards thrombin and FXIIa using capillary electrophoresis
Publication date :
19 December 2018
Event name :
CIRM-day
Event place :
Liège, Belgium
Event date :
19 décembre 2018
Name of the research project :
Development of new compounds targeting coagulation factor XIIa using innovative microfluidic assays in the context of fragment-based drug discovery
