Emerging Roles for the Unfolded Protein Response in the Developing Nervous System

[en] The unfolded protein response (UPR) is a homeostatic signaling pathway triggered by protein misfolding in the endoplasmic reticulum (ER). Beyond its protective role, it plays important functions during normal development in response to elevated demand for protein folding. Several UPR effectors show dynamic temporal and spatial expression patterns that correlate with milestones of the central nervous system (CNS) development. Here, we discuss recent studies suggesting that a dynamic regulation of UPR supports generation, maturation, and maintenance of differentiated neurons in the CNS. We further highlight studies supporting a developmental vulnerability of CNS to UPR dysregulation, which underlies neurodevelopmental disorders. We believe that a better understanding of UPR functions may provide novel opportunities for therapeutic strategies to fight ER/UPR-associated human neurological disorders. © 2016 Elsevier Ltd.

Research center :

Giga-Neurosciences - ULiège

Disciplines :

Neurology

Author, co-author :

Godin, Julie ; Université de Liège - ULiège > Département des sciences sociales > Socio-anthropologie du développement

Creppe, C.; GIGA-Neurosciences, University of Liège, C.H.U. Sart Tilman, Liège, Belgium, Interdisciplinary Cluster for Applied Genoproteomics (GIGA-R), University of Liège, C.H.U. Sart Tilman, Liège, Belgium

Laguesse, Sophie ; Université de Liège - ULiège > Giga - Neurosciences

Nguyen, Laurent ; Université de Liège - ULiège > GIGA - Neurosciences

Language :

English

Title :

Emerging Roles for the Unfolded Protein Response in the Developing Nervous System

Publication date :

2016

Journal title :

Trends in Neurosciences

ISSN :

0166-2236

Publisher :

Elsevier Ltd

Volume :

Issue :

Pages :

394-404

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 02 May 2019

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