Article (Scientific journals)
Is Sclerostin Glycoprotein a Suitable Biomarker for Equine Osteochondrosis?
Mendoza, L.; Franck, Thierry; Lejeune, Jean-Philippe et al.
2018In Journal of Equine Veterinary Science, 64, p. 27-33
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Keywords :
Biomarker; Equine; Osteochondrosis; Sclerostin; Wnt pathway
Abstract :
[en] Osteochondrosis (OC) disease appears to be multifactorial in origin, including skeletal growth rates, nutrition, endocrinological factors, exercise, biomechanics, and other environmental factors. Endocrinological and metabolic factors seem to have an important role in the pathogeny of OC like the Wnt signaling pathway. One of the regulators in the Wnt signaling pathway is the sclerostin glycoprotein. The aim of this study was to investigate the sclerostin blood concentration according to the evolution of the disease, the environment, and the age but also its use as a possible biomarker for OC disease. Relation between age and sclerostin concentrations was calculated by a linear regression. A relation was found between age and sclerostin concentrations, but also a significant relation between age and the sclerostin concentrations was observed for two subgroups (OC affected and healthy). Evolution of the disease related to the sclerostin concentration was assessed with two logistic regressions (risk of developing OC and recovery of existing lesions), but not any significance was found. In conclusion, these results show that, despite the possible link of sclerostin with the OC pathogenesis through the Wnt pathway, circulating levels of this glycoprotein shall not be used as a biomarker for the disease. Besides, more studies are needed to fully understand the functions of sclerostin in the equine specie since it may play an important role in bone homeostasis. © 2017 Elsevier Inc.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Mendoza, L.;  Anesthésiologie générale et pathologie chirurgicale des grands animaux. University of Liège, Liège, Belgium, Equine Research and Development Center, Mont-le-Soie, Belgium
Franck, Thierry  ;  Université de Liège - ULiège > Centre de l'oxygène : Recherche et développement (C.O.R.D.)
Lejeune, Jean-Philippe ;  Université de Liège - ULiège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Pathologie médicale des petits animaux
Caudron, Isabelle ;  Université de Liège - ULiège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Dép. clinique des animaux de compagnie et des équidés (DCA)
Detilleux, Johann ;  Université de Liège - ULiège > Dpt. de gestion vétérinaire des Ressources Animales (DRA) > Génétique quantitative
Deliège, B.;  Equine Research and Development Center, Mont-le-Soie, Belgium
Serteyn, Didier  ;  Université de Liège - ULiège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Anesthésiologie gén. et pathologie chirurg. des grds animaux
Language :
English
Title :
Is Sclerostin Glycoprotein a Suitable Biomarker for Equine Osteochondrosis?
Publication date :
2018
Journal title :
Journal of Equine Veterinary Science
ISSN :
0737-0806
eISSN :
1542-7412
Publisher :
W.B. Saunders
Volume :
64
Pages :
27-33
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 24 April 2019

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