Rapid testosterone-induced growth of the medial preoptic nucleus in male canaries.

[en] Testosterone activates singing within days in castrated male songbirds but full song quality only develops after a few weeks. Lesions of the medial preoptic nucleus (POM) inhibit while stereotaxic testosterone implants into this nucleus increase singing rate suggesting that this site plays a key role in the regulation of singing motivation. Testosterone action in the song control system works in parallel to control song quality. Accordingly, systemic testosterone increases POM volume within 1-2days in female canaries, while the increase in volume of song control nuclei takes at least 2weeks. The current study tested whether testosterone action is associated with similar differences in latencies in males. Photosensitive castrated male canaries were implanted with testosterone-filled Silastic implants and control castrates received empty implants, while simultaneously the photoperiod was switched from short- to long-days. Brains were collected from all subjects two days later. Plasma testosterone was elevated in testosterone-treated but not in controls. HVC volumes were not affected, but testosterone significantly increased the POM volume as identified by the dense group of aromatase-immunoreactive neurons, the number and somal area of these neurons and the fractional area they cover in POM. Testosterone-treated females from a previous experiment had a smaller POM volume in similar conditions suggesting the existence of a stable sex difference potentially affecting singing behavior. Thus testosterone induces male POM growth and aromatase expression in this nucleus within two days without affecting HVC size, further supporting the notion that testosterone increases singing motivation via its action in POM.

Research center :

Giga-Neurosciences - ULiège

Disciplines :

Neurosciences & behavior

Author, co-author :

Shevchouk, Olesya T.

Ball, Gregory F.

Cornil, Charlotte ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie de la différenciation sexuelle du cerveau

Balthazart, Jacques ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques

Language :

English

Title :

Rapid testosterone-induced growth of the medial preoptic nucleus in male canaries.

Publication date :

2019

Journal title :

Physiology and Behavior

ISSN :

0031-9384

eISSN :

1873-507X

Publisher :

Elsevier, New-York, United States - New York

Volume :

204

Pages :

20-26

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

PAI

Commentary :

Available on ORBi :

since 23 April 2019

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