A domain of TEL conserved in a subset of ETS proteins defines a specific oligomerization interface essential to the mitogenic properties of the TEL-PDGFR beta oncoprotein.

Jousset, C.; Carron, C.; Boureux, A.; Quang, C. T.; Oury, Cécile; Dusanter-Fourt, I.; Charon, M.; Levin, J.; Bernard, Olivier A; Ghysdael, Jacques

doi:10.1093/emboj/16.1.69

Article (Scientific journals)

A domain of TEL conserved in a subset of ETS proteins defines a specific oligomerization interface essential to the mitogenic properties of the TEL-PDGFR beta oncoprotein.

Jousset, C.; Carron, C.; Boureux, A. et al.

1997 • In EMBO Journal

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/23469

DOI
10.1093/emboj/16.1.69

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9009269

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Keywords :

leukemia; chromosomal translocation; ETS transcription factors

Abstract :

[en] TEL is a novel member of the ETS family of transcriptional regulators which is frequently involved in human leukemias as the result of specific chromosomal translocations. This study shows that the amino-terminal domain conserved in a subset of the ETS proteins has evolved to generate a specialized protein-protein interaction interface which is likely to be an important determinant of their specificity as transcriptional regulators.

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Jousset, C.; Institut Curie (France) > CNRS UMR 146

Carron, C.; Institut Curie (France) > CNRS UMR 146

Boureux, A.; Institut Curie (France) > CNRS UMR 146

Quang, C. T.; Institut Curie (France) > CNRS UMR 146

Oury, Cécile ; Institut Curie (France) > CNRS UMR 146

Dusanter-Fourt, I.; Institut Cochin de Génétique Moléculaire > INSERM U 363

Charon, M.; Institut Cochin de Génétique Moléculaire > INSERM U 363

Levin, J.; Institut National de la Recherche Agronomique (France)

Bernard, Olivier A; Institut de Génétique Moléculaire (France) > INSERM U 301

Ghysdael, Jacques; Institut Curie (France) > CNRS UMR 146

Language :

English

Title :

A domain of TEL conserved in a subset of ETS proteins defines a specific oligomerization interface essential to the mitogenic properties of the TEL-PDGFR beta oncoprotein.

Publication date :

1997

Journal title :

EMBO Journal

ISSN :

0261-4189

eISSN :

1460-2075

Publisher :

Oxford University Press, Oxford, United Kingdom

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 23 September 2009

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Bibliography

Bailly, R., Bosselut, R., Zucman, J., Cormier, F., Delattre, O., Roussel, M., Thomas, G. and Ghysdael, J. (1994) DNA-binding and transcriptional activation properties of the EWS-FLI-1 fusion protein resulting from the t(11;22) translocation in Ewing sarcoma. Mol. Cell. Biol., 14, 3230-3241
Bargmann, C.I., Hung, M.C. and Weinberg, R.A. (1986) Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185. Cell, 45, 649-657.
Ben-David, Y., Giddens, E., Letwin, K. and Bernstein, A. (1991) Erythroleukemia induction by Friend murine leukemia virus: insertional activation of a new member of the ets gene family, Fli-1, closely linked to c-ets-1. Genes Dev., 5, 908-918.
Bishayee, S., Majumdar, S., Khire, J. and Das, M. (1989) Ligand-induced dimerization of the platelet-derived growth factor receptor. Monomer-dimer interconversion occurs independently of receptor phosphorylation. J. Biol. Chem., 264, 11699-11705.
Bongarzone, I., Monzini, N., Borrello, M.G., Carcano, C., Ferraresi, G., Arighi, E., Mondellini, P., Della Porta, G. and Pierotti, M.A. (1993) Molecular characterization of a thyroid tumor-specific transforming sequence formed by the fusion of ret tyrosine kinase and the regulatory subunit RI alpha of cyclic AMP-dependent protein kinase A. Mol. Cell. Biol., 13, 358-366.
Bones, J.C., Willerford, D.M., Grevin, D., Davidson, L., Camus, A., Martin, P., Stehelin, D. and Alt, F.W. (1995) Increased T-cell apoptosis and terminal B-cell differentiation induced by inactivation of the Ets-1 proto-oncogene. Nature, 377, 635-638.
Boulukos, K., Pognonec, P., Begue, A., Galibert, F., Gesquiere, J., Stehelin, D. and Ghysdael, J. (1988) Identification in chickens of an evolutionary conserved cellular ets-2 gene (c-ets-2) encoding nuclear proteins related to the products of the c-ets proto-oncogene. EMBO J., 7, 697-705.
Boulukos, K., Pognonec, P., Rabault, B., Begue, A. and Ghysdael, J. (1989) Definition of an Ets1 protein domain required for nuclear localization in cells and DNA-binding activity in vitro. Mol. Cell. Biol., 9, 5718-5721.
Brown, T.A. and McKnight, S.L. (1992) Specificities of protein-protein and protein-DNA interaction of GABP alpha and two newly defined ets-related proteins. Genes Dev., 6, 2502-2512.
Brunner, D., Ducker, K., Oellers, N., Hafen, E., Scholz, H. and Klambt, C. (1994) The ETS domain protein pointed-P2 is a target of MAP kinase in the sevenless signal transduction pathway. Nature, 370, 386-389.
Buijs, A. et al. (1995) Translocation (12:22) (p13;q11) in myeloproliferative disorders results in fusion of the ETS-like TEL gene on 12p13 to the MN1 gene on 22q11. Oncogene, 10, 1511-1519.
Claesson-Welsh, L., Eriksson, A., Moren, A., Severinsson, L., Ek, B., Ostman, A., Betsholtz, C. and Heldin, C.H. (1988) cDNA cloning and expression of a human platelet-derived growth factor (PDGF) receptor specific for B-chain-containing PDGF molecules. Mol. Cell. Biol., 8, 3476-3486.
Daley, G.Q. and Baltimore, D. (1988) Transformation of an interleukin 3-dependent hematopoietic cell line by the chronic myelogenous leukemia-specific P210bcr/abl protein. Proc. Natl Acad. Sci. USA, 85, 9312-9316.
Daley, G.Q., Van Etten, R.A., Jackson, P.K., Bernards, A. and Baltimore, D. (1992) Nonmyristoylated AbI proteins transform a factor-dependent hematopoietic cell line. Mol. Cell. Biol., 12, 1864-1871.
Dalton, S. and Treisman, R. (1992) Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element. Cell. 68, 597-612.
Damen, J., Wakao, H., Miyajima, A., Krosl, J., Humphries, K., Cutler, R. and Krystal, G. (1995) Tyrosine 343 in the erythropoietin receptor positively regulates erythropoietin-induced cell proliferation and Stat 5 activation. EMBO J., 14, 5557-5568.
de Parseval, N., Fichelson, S., Mayeux, P., Gisselbrecht, S. and Sola, B. (1993) Expression of functional beta-platelet-derived growth factor receptors on hematopoietic cell lines. Cytokine, 5, 8-15.
Delattre, O. et al. (1992) Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours. Nature, 359, 162-165.
Delgado, M., Hallier, M., Meneceur, P., Tavitian, A. and Moreau-Gachelin, F. (1994) Inhibition of Friend cells proliferation by spi-1 antisense oligodeoxynucleotides. Oncogene, 9, 1723-1727.
Donaldson, L.W., Petersen, J.M., Graves, B.J. and McIntosh, L.P. (1994) Secondary structure of the ETS domain places murine Ets-1 in the superfamily of winged helix-turn-helix DNA-binding proteins. Biochemistry, 33, 13509-13516.
Donaldson, L.W., Petersen, J.M., Graves, B.J. and McIntosh, L.P. (1996) Solution structure of the ETS domain from murine Ets-1: a winged helix-turn-helix DNA binding motif. EMBO J., 15, 125-134.
Dusanter-Fourt, I. et al. (1994) Identification of JAK protein tyrosine kinases as signaling molecules for prolactin. Functional analysis of prolactin receptor and prolactin-erythropoietin receptor chimera expressed in lymphoid cells. EMBO J., 13, 2583-2591.
Frangioni, J.V. and Neel, B.G. (1993) Solubiliziation and purification of enzymatically active glutathione S-transferase (pGex) fusion proteins. Anal. Biochem., 210, 179-187.
Gegonne, A., Punyammalee, B., Rabault, B., Bosselut, R., Seneca, S., Crabeel, M. and Ghysdael, J. (1992) Analysis of the DNA binding and transcriptional activation properties of the Ets1 oncoprotein. New Biol., 4, 512-519.
Gegonne, A., Bosselut, R., Bailly, R.A. and Ghysdael, J. (1993) Synergistic activation of the HTLV1 LTR Ets-responsive region by transcription factors Ets1 and Sp1. EMBO J., 12, 1169-1178.
Ghysdael, J., Gegonne, A., Pognonec, P. Boulukos, K., Leprince, D., Dernis, D., Lagrou, C. and Stehelin, D. (1986) Identification in chicken macrophages of a set of proteins related to, but distinct from the chicken cellular c-ets-encoded protein p54c-ets. EMBO J., 5, 2251-2256.
Giese, K., Kingsley, C., Kirshner, J.R. and Grosschedl, R. (1995) Assembly and function of a TCR alpha enhancer complex is dependent on LEF1-induced DNA bending and multiple protein-protein interactions. Genes Dev., 9, 995-1008.
Gobert, S. et al. (1995) Tyrosine phosphorylation of the erythropoietin receptor: role for differentiation and mitogenic signal transduction. Blood, 86, 598-606.
Golub, T.R., Barker, G.F., Lovett, M. and Gilliland, D.G. (1994) Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation. Cell, 77, 307-316.
Golub, T.R. et al. (1995) Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia. Proc. Natl Acad. Sci. USA, 92, 4917-4921.
Greco, A., Pierotti, M.A., Bongarzone, I., Pagliardini, S., Lanzi, C. and Della Porta, G. (1992) TRK-T1 is a novel oncogene formed by the fusion of TPR and TRK genes in human papillary thyroid carcinomas. Oncogene, 7, 237-242.
Grieco, M. et al. (1990) PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas. Cell, 60, 557-563.
Gugneja, S., Virbasius, J.V. and Scarpulla, R.C. (1995) Four structurally distinct, non-DNA-binding subunits of human nuclear respiratory factor 2 share a conserved transcriptional activation domain. Mol. Cell. Biol., 15, 102-111.
Heldin, C.H. (1995) Dimerization of cell surface receptors in signal transduction. Cell. 80, 213-223.
Heldin, C.H., Ernlund, A., Rorsman, C. and Ronnstrand, L. (1989) Dimerization of B-type platelet-derived growth factor receptors occurs after ligand binding and is closely associated with receptor kinase activation. J. Biol. Chem., 264, 8905-8912.
Hiebert, S.W. et al. (1996) The t(12;21) translocation converts AML-1B from an activator to a repressor of transcription. Mol. Cell. Biol., 15, 1786-1796.
Hill, C.S. and Treisman, R. (1995) Differential activation of c-fos promoter elements by serum, lysophosphatidic acid, G proteins and polypeptide growth factors. EMBO J., 14, 5037-5047.
Hipskind, R., Rao, V., Mueller, C., Reddy, E. and Nordheim, A. (1991) Ets-related protein Elk-1 is homologous to the c-fos regulatory factor p62TCF. Nature, 354, 531-534.
Ichikawa, H., Shimizu, K., Hayashi, Y. and Ohki, M. (1994) An RNA-binding protein gene, TLS/FUS, is fused to ERG in human myeloid leukemia with t(16;21) chromosomal translocation. Cancer Res., 54, 2865-2868.
Inaba, T. et al. (1993) Expression of platelet-derived growth factor beta receptor on human monocyte-derived macrophages and effects of platelet-derived growth factor BB dimer on the cellular function. J. Biol. Chem., 268, 24353-24360.
Janknecht, R., Ernst, W.H. and Nordheim, A. (1995) SAP1α is a nuclear target of signaling cascades involving ERKs. Oncogene, 10, 1209-1216.
Jeon, I.S., Davis, J.N., Braun, B.S., Sublett, J.E., Roussel, M.F., Denny, C.T. and Shapiro, D.N. (1995) A variant Ewing's sarcoma translocation (7; 22) fuses the EWS gene to the ETS sene ETV1. Oncogene, 10, 1229-1234.
John, S., Reeves, R.B., Lin, J.X., Child, R., Leiden, J.M., Thompson, C.B. and Leonard, W.J. (1995) Regulation of cell-type-specific interleukin-2 receptor alpha-chain gene expression: potential role of physical interactions between Elf-1, HMG-I(Y), and NF-kappa B family proteins. Mol. Cell. Biol., 15, 1786-1796.
Klambt, C. (1993) The Drosophila gene pointed encodes two ETS-like proteins which are involved in the development of the midline glial cells. Development, 117, 163-176.
Kodandapani, R., Pio, F., Ni, C., Picciali, G., Klemsz, M., McKercher, S., Maki, R.A. and Ely, K.R. (1996) A new pattern for helix-turn-helix recognition revealed by the PU.1 ETS domain-DNA complex. Nature, 380, 456-460.
LaMarco, K., Thompson, C.C., Byers, B.P., Walton, E.M. and McKnight, S.L. (1991) Identification of Ets-and notch-related subunits in GA binding protein. Science, 253, 789-792.
Leprince, D., Gegonne, A., Coll, J., de Taisne, C., Schneeberger, A., Lagrou, C. and Stehelin, D. (1983) A putative second cell-derived oncogene of the avian leukaemia retrovirus E26. Nature, 306, 395-397.
Levin, J.M. and Garnier, J. (1988) Improvements in a secondary structure prediction method based on a search for local sequence homologies and its use as a model building tool. Biochim. Biophys. Acta, 955, 283-295.
Levin, J.M., Pascarella, S., Argos, P. and Garnier, J. (1993) Quantification of secondary structure prediction improvement using multiple alignments. Protein Engng, 6, 849-854.
Liang, H., Mao, X., Olejniczak, E.T., Nettesheim, D.G., Yu, L., Meadows, R.P. Thompson, C.B. and Fesik, S.W. (1994) Solution structure of the ets oomain of Fli-1 when bound to DNA. Nature Struct. Biol., 1, 871-875.
Ma, P.C., Rould, M.A., Weintraub, H. and Pabo, C.O. (1994) Crystal structure of MyoD bHLH domain-DNA complex: perspectives on DNA recognition and implications for transcriptional activation Cell, 77, 451-459.
Mathey-Prevot, B., Nabel, G., Palacios, R. and Baltimore, D. (1986) Abelson virus abrogation of interleukin-3 dependence in a lymphoid cell line. Mol. Cell. Biol., 6, 4133-4135.
May, W.A., Gishizky, M.L., Lessnick, S.L., Lunsford, L.B., Lewis, B.C., Delattre, O., Zucman, J., Thomas, G. and Denny, C.T. (1993a) Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation. Proc. Natl Acad. Sci. USA, 90, 5752-5756.
May, W.A., Lessnick, S.L., Braun, B.S., Klemsz, M., Lewis, B.C., Lunsford, L.B., Hromas, R. and Denny, C.T. (1993b) The Ewing's sarcoma EWS/ FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1. Mol. Cell. Biol., 13, 7393-7398.
McWhirter, J.R. and Wang, J.Y. (1993) An actin-binding function contributes to transformation by the Bcr-Abl oncoprotein of Philadelphia chromosome-positive human leukemias. EMBO J., 12, 1533-1546.
McWhirter, J.R., Galasso, D.L. and Wang, J.Y. (1993) A coiled-coil oligomerization domain of Bcr is essential for the transforming function of Bcr-Abl oncoproteins. Mol. Cell. Biol., 13, 7587-7595.
Metz, T. and Graf, T. (1991a) Fusion of the nuclear oncoproteins v-Myb and v-Ets is required for the leukemogenicity of E26 virus. Cell, 66, 95-105.
Metz, T. and Graf, T. (1991b) v-myb and v-ets transform chicken erythroid cells and cooperate both in trans and in cis to induce distinct differentiation phenotypes. Genes Dev., 5, 369-380.
Miyazaki, T., Liu, Z.J., Kawahara, A., Minami, Y. Yamada, K., Tsujimoto, Y., Barsoumian, E.L., Permutter, R.M. and Taniguchi, T. (1995) Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation. Cell, 81, 223-231.
Moreau-Gachelin, F., Tavitian, A. and Tambourin, P. (1988) Spi-1 is a putative oncogene in virally induced murine erythroleukaemias. Nature, 331, 277-280.
Morgenstern, J.P. and Land, H. (1990) Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line. Nucleic Acids Res., 18, 3587-3596.
Muthusamy, N., Barton, K. and Leiden, J.M. (1995) Defective activation and survival of T cells lacking the Ets-1 transcription factor. Nature, 377, 639-642.
Nunn, M.E. Seeburg, P.H., Moscovici, C. and Duesberg, P.H. (1983) Tripartite structure of the avian erythroblastosis virus E26 transforming gene. Nature, 306, 391-395.
Nye, J.A., Petersen, J.M., Gunther, C.V., Jonsen, M.D. and Graves, B.J. (1992) Interaction of murine ets-1 with GGA-binding sites establishes the ETS domain as a new DNA-binding motif. Genes Dev., 6, 975-990.
O'Neil, E., Rebay, I., Tjian, R. and Rubin, G. (1994) The activities of two Ets-related transcription factors required for Drosophila eye development are modulated by the Ras/MAPK pathway. Cell, 78, 137-147.
Palacios, R. and Steinmetz, M. (1985) IL-3-dependent mouse clones that express B-220 surface antigen, contain Ig genes in germ-line configuration, and generate B lymphocytes in vivo. Cell, 41, 727-734.
Pamazis, P., Kharbanda, S., Goustin, A.S., Galanopoulos, T. and Kufe, D. (1991) Coexpression of the genes for platelet-derived growth factor B-chain receptor and macrophage colony-stimulating factor 1 receptor during monocytic differentiation. Proc. Natl Acad. Sci. USA, 88, 2481-2485.
Papadopoulos, P., Ridge, S.A., Boucher, C.A., Stocking, C. and Wiedemann, L.M. (1995) The novel activation of ABL by fusion to an ets-related gene, TEL. Cancer. Res., 55, 34-38.
Poirel, H. et al. (1997) The TEL gene products: nuclear proteins with DNA-binding properties. Oncogene, in press.
Pongubala, J.M., Nagulapalli, S., Klemsz, M.J., McKercher, S.R., Maki, R.A. and Atchison, M.L. (1992) PU.1 recruits a second nuclear factor to a site important for immunoglobulin kappa 3′ enhancer activity. Mol. Cell. Biol., 12, 368-378.
Prasad, D.D., Ouchida, M., Lee, L., Rao, V.N. and Reddy, E.S. (1994) TLS/ FUS fusion domain of TLS/FUS-erg chimeric protein resulting from the t(16;21) chromosomal translocation in human myeloid leukemia functions as a transcriptional activation domain. Oncogene, 9, 3717-3729.
Rabault, B. and Ghysdael, J. (1994) Calcium-induced phosphorylation of ETS1 inhibits its specific DNA binding activity. J. Biol. Chem., 269, 28143-28151.
Rabault, B., Roussel, M.F., Tran Quang, C. and Ghysdael, J. (1996) Phosphorylation of Ets1 regulates the complementation of a CSF-1 receptor impaired in mitogenesis. Oncogene, 13, 877-881.
Rao, V.N., Ohno, T., Prasad, D.D., Bhattacharya, G. and Reddy, E.S. (1993) Analysis of the DNA-binding and transcriptional activation functions of human Fli-1 protein. Oncogene, 8, 2167-2173.
Rebay, I. and Rubin, G.M. (1995) Yan functions as a general inhibitor of differentiation and is negatively regulated by activation of the Ras1/ MAPK pathway. Cell, 81, 857-866.
Reddy, E.S., Rao, V.N. and Papas, T.S. (1987) The erg gene: a human gene related to the ets oncogene. Proc. Natl Acad. Sci. USA, 84, 6131-6135.
Rodrigues, G.A. and Park, M. (1993) Dimerization mediated through a leucine zipper activates the oncogenic potential of the met receptor tyrosine kinase. Mol. Cell. Biol., 13, 6711-6722.
Romana, S.P. Poirel, H., Leconiat, M., Flexor, M.A., Mauchauffe, M., Jonveaux, P., Macintyre, E.A., Berger, R. and Bernard, O.A. (1995) High frequency of t(12;21) in childhood B-lineage acute lymphoblastic leukemia. Blood, 86, 4263-4269.
Schneikert, J., Lutz, Y. and Wasylyk, B. (1992) Two independent activation domains in c-Ets-1 and c-Ets-2 located in non-conserved sequences of the ets gene family. Oncogene, 7, 249-256.
Schuetze, S., Stenberg, P.E. and Kabat, D. (1993) The Ets-related transcription factor PU.1 immortalizes erythroblasts. Mol. Cell. Biol., 13, 5670-5678.
Scott, E.W., Simon, C., Anastasi, J. and Singh, H. (1994) Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages. Structural basis for DNA bending by the architectural transcription factor LEF-1. Science, 265, 1573-1577.
Seth, A. and Papas, T.S. (1990) The c-ets-1 proto-oncogene has oncogenic activity and is positively autoregulated. Oncogene, 5, 1761-1767.
Shimizu, K., Ichikawa, H., Tojo, A., Kaneko, Y., Maseki, N., Hayashi, Y., Ohira, M., Asano, S. and Ohki, M. (1993) An ets-related gene, ERG, is rearranged in human myeloid leukemia with t(16;21) chromosomal translocation. Proc. Natl Acad. Sci. USA, 90, 10280-10284.
Sieweke, M.H., Tekotte, H., Frampton, J. and Graf, T. (1996) MafB is an interaction partner and repressor of Ets-1 that inhibits erythroid differentiation. Cell, 85, 49-60.
Thompson, C.C., Brown, T.A. and McKnight, S.L. (1991) Convergence of Ets-and notch-related structural motifs in a heteromeric DNA binding complex. Science, 253, 762-768.
Thompson, J.D., Higgins, D.G. and Gibson, T.J. (1994) CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res., 22, 4673-4680.
Tran Quang, C., Pironin, M., Von Lindern, M., Beug, H. and Ghysdael, J. (1995) Spi-1 and mutant p53 regulate different aspects of the proliferation and differentiation of primary erythroid progenitors. Oncogene, 11, 1229-1239.
Virbasius, J.V., Virbasius, C.A. and Scarpulla, R.C. (1993) Identity of GABP with NRF-2, a multisubunit activator of cytochrome oxidase expression, reveals a cellular role for an ETS domain activator of viral promoters. Genes Dev., 7, 380-392.
Wassarman, D.A., Therrien, M. and Rubin, G.M. (1995) The Ras signaling pathway in Drosophila. Curr. Opin. Genet. Dev., 5, 44-50.
Wasylyk, B., Wasylyk, C. Flores, P., Begue, A., Leprince, D. and Stehelin, D. (1990) The c-ets proto-oncogenes encode transcription factors that cooperate with c-Fos and c-Jun for transcriptional activation. Nature, 346, 191-193.
Wasylyk, B., Hahn, S.L. and Giovane, A. (1993) The Ets family of transcription factors. Eur. J. Biochem., 211, 7-18.
Watanabe, H., Sawada, J., Yano, K., Yamaguchi, K., Goto, M. and Handa, H. (1993) cDNA cloning of transcription factor E4TF1 subunits with Ets and notch motifs. Mol. Cell. Biol., 13, 1385-1391.
Weiner, D.B., Liu, J., Cohen, J.A., Williams, W.V. and Greene, M.I. (1989) A point mutation in the neu oncogene mimics ligand induction of receptor aggregation. Nature, 339, 230-231.
Williams, L.T. (1989) Signal transduction by the platelet-derived growth factor receptor. Science, 243, 1564-1570.
Woods, D., Ghysdael, J. and Owen, M. (1992) Identification of nucleotide preferences in DNA sequences recognised specifically by c-Ets-1 protein. Nucleic Acids Res., 20, 699-704.
Wotton, D., Prosser, H.M. and Owen, M.J. (1993) Regulation of human T cell receptor beta gene expression by Ets-1. Leukemia, 7, S55-60.
Yang, B.S., Hauser, C.A., Henkel, G., Colman, M.S., Van Beveren, C., Stacey, K.J., Hume, D.A., Maki, R.A. and Ostrowski, M.C. (1996) Ras-mediated phosphorylation of a conserved threonine residue enhances the transactivation activities of c-Ets1 and c-Ets2. Mol. Cell. Biol., 16, 538-547.
Zucman, J. et al. (1993) Combinatorial generation of variable fusion proteins in the Ewing family of tumours. EMBO J., 12, 4481-4487.