The TEL gene products: nuclear phosphoproteins with DNA binding properties.

[en] The human TEL gene is involved in several 12p13 chromosomal abnormalities present in various human hematological malignancies, the most frequent being the t(12;21)(p13;q22), specific for childhood acute lymphoblastic leukemia. The predicted product of TEL harbours an amino acid region similar to the ETS DNA binding domain. We now report the isolation of the murine TEL cDNA and the characterization of the human TEL proteins. Human and murine TEL proteins are particularly homologous within their aminoterminal regions and their ETS domains. TEL proteins are nuclear and display specific DNA binding activity toward classical ETS binding sites. In addition, we show that TEL mRNAs initiate translation at either of the two first inframe ATGs (codon 1 and 43) to encode 50 kDa and 57 kDa TEL proteins. In vivo, each of these primary translational products is modified by multiple phosphorylation events.

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Poirel, H.; Institut de Génétique Moléculaire (France) > INSERM U 301

Oury, Cécile ; Institut Curie (France) > CNRS UMR 146

Carron, Clémence; Institut Curie (France) > CNRS UMR 146

Duprez, E.

Laabi, Y.

Tsapis, A.

Romana, S. P.

Mauchauffe, M.

Le Coniat, M.

Berger, R.

Ghysdael, Jacques; Institut Curie (France) > CNRS UMR 146

Bernard, Olivier A; Institut de Génétique Moléculaire (France) > INSERM U 301

Language :

English

Title :

The TEL gene products: nuclear phosphoproteins with DNA binding properties.

Publication date :

1997

Journal title :

Oncogene

ISSN :

0950-9232

eISSN :

1476-5594

Publisher :

Nature Publishing Group, Basingstoke, United Kingdom

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 23 September 2009

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