The TEL gene products: nuclear phosphoproteins with DNA binding properties.

[en] The human TEL gene is involved in several 12p13 chromosomal abnormalities present in various human hematological malignancies, the most frequent being the t(12;21)(p13;q22), specific for childhood acute lymphoblastic leukemia. The predicted product of TEL harbours an amino acid region similar to the ETS DNA binding domain. We now report the isolation of the murine TEL cDNA and the characterization of the human TEL proteins. Human and murine TEL proteins are particularly homologous within their aminoterminal regions and their ETS domains. TEL proteins are nuclear and display specific DNA binding activity toward classical ETS binding sites. In addition, we show that TEL mRNAs initiate translation at either of the two first inframe ATGs (codon 1 and 43) to encode 50 kDa and 57 kDa TEL proteins. In vivo, each of these primary translational products is modified by multiple phosphorylation events.

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Poirel, H.; Institut de Génétique Moléculaire (France) > INSERM U 301

Oury, Cécile ; Institut Curie (France) > CNRS UMR 146

Carron, Clémence; Institut Curie (France) > CNRS UMR 146

Duprez, E.

Laabi, Y.

Tsapis, A.

Romana, S. P.

Mauchauffe, M.

Le Coniat, M.

Berger, R.

Ghysdael, Jacques; Institut Curie (France) > CNRS UMR 146

Bernard, Olivier A; Institut de Génétique Moléculaire (France) > INSERM U 301

Language :

English

Title :

The TEL gene products: nuclear phosphoproteins with DNA binding properties.

Publication date :

1997

Journal title :

Oncogene

ISSN :

0950-9232

eISSN :

1476-5594

Publisher :

Nature Publishing Group, Basingstoke, United Kingdom

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 23 September 2009

Statistics

Number of views

25 (1 by ULiège)

Number of downloads

1 (1 by ULiège)

More statistics

Scopus citations^®

Scopus citations^®
without self-citations

OpenCitations

Bibliography

Bailly RA, Bosselut R, Zucman J, Cormier F, Delattre O, Roussel M, Thomas G and Ghysdael J. (1994). Mol. Cell. Biol., 14, 3230-3241.
Bernard OA, Romana SP, Poirel H and Berger R. (1996). Leukemia & Lymphoma, in press.
Bosselut R, Duvall JF, Gégonne A, Bailly M, Hémar A, Brady J and Ghysdael J. (1990). EMBO J., 9, 3137-3144.
Bosselut R, Levin J, Adjadj E and Ghysdael J. (1993). Nucleic Acids Res., 21, 5184-5191.
Boulukos K, Pognonec P, Rabault B, Begue A and Ghysdael J. (1989). Mol. Cell. Biol., 9, 5718-5721.
Brunner D, Ducker K, Oellers N, Hafen E, Scholz H and Klambt C. (1994). Nature, 370, 386-389.
Buijs A, Sherr S, van Baal S, van Bezouw S, van der Plas D, van Kessel AG, Riegman P, Lekanne Deprez R, Zwarthoff E, Hagemeijer A and Grosveld G. (1995). Oncogene, 10, 1511-1519.
Cavé H, Gérard B, Martin E, Guidal C, Devaux I, Weissenbach J, Elion J, Vilmer E and Grandchamp B. (1995). Blood, 86, 3869-3875.
Delattre O, Zucman J, Plougastel B, Desmaze C, Melot T, Peter M, Kovar H, Joubert I, de Jong P, Rouleau G, Aurias A and Thomas G. (1992). Nature, 359, 162-165.
Ghysdael J. (1995). Path. Biol., 43, 202-207.
Giovane A, Pnitzas A, Sauveur-Michel M, Sobieszczuk P and Wasylyk B. (1994). Genes & Dev., 8, 1502-1513.
Golub TR, Barker FG, Lovett M and Gilliland DG. (1994). Cell, 77, 307-316.
Golub TR, Barker FG, Bohlander SK, Hiebert SW, Ward DC, Bray-Ward P, Morgan E, Raimondi SC, Rowley JD and Gilliland DG. (1995). Proc. Natl. Acad. Sci. USA, 92, 4917-4921.
Golub T, Goga A, Barker G, Afar D, McLaughlin L, Bohlander S, Rowley J, Witte O and Gilliland DG. (1996). Mol. Cell. Biol., 16, 4107-4116.
Hiebert SW, Sun W-H, Davis N, Golub T, Shurtleff S, Buijs A, Downing JR, Grosveld G, Roussel M, Gilliland GD, Lenny N and Meyers S. (1996). Mol. Cell. Biol., 16, 1349-1355.
Ichikawa H, Shimizu K, Hayashi Y and Ohki M. (1994). Cancer Res., 54, 2865-2868.
Janknecht R, Ernst WH and Nordheim A. (1995). Oncogene, 10, 1209-1216.
Janknecht R, Ernst WH, Pingoud V and Nordheim A. (1993). EMBO J., 12, 5097-5104.
Jeon I-S, Davis JN, Braun BS, Sublett JE, Roussel MF, Denny CT and Shapiro DN. (1995). Oncogene, 10, 1229-1234.
Kozak M. (1986). Cell, 44, 283-292.
Marais R, Wynne J and Treisman R. (1993). Cell, 73, 381-393.
May WA, Lessnick SL, Braun BS, Klemsz M, Lewis BC, Lunsford LB, Hromas R and Denny CT. (1993). Mol. Cell. Biol., 13, 7393-7398.
McLean TW, Ringold S, Stegmaier K, Neuberg D, Trantavahi R, Ritz J, Koeffler HP, Takeuchi S, Janssen JWG, Seriu T, Bartram CR, Sallan SE, Gilliand DG and Golub TR. (1996). Blood, in press.
Meyers S and Hiebert SW. (1995). Crit. Rev. Euk. Gene Exp., 5, 365-383.
Papadopoulos R, Ridge SA, Boucher CA, Stocking C and Wiedemann LM. (1995). Cancer Res., 55, 34-38.
Pongubala JMR, Van Beveren C, Nagulapalli S, Klemsz MJ, McKercher SR, Maki RA and Atchinson ML. (1993). Science, 259, 1622-1625.
Price MA, Rogers AE and Treisman R. (1995). Embo J., 14, 2589-2601.
Rabault B and Ghysdael J. (1994). J. Biol. Chem., 269, 28143-28151.
Rabault B, Roussel MF, Tran Quang C and Ghysdael J. (1996). Oncogene, 13, 877-881.
Rabbitts TH. (1994). Nature, 371, 143-149.
Raynaud S, Cave H, Baens M, Bastard C, Cacheux V, Grosgeorge J, Guidal-Giroux C, Guo C, Vilmer E, Marynen P and Grandchamp B. (1996). Blood, 87, 2891-2899.
Rebay I and Rubin GM. (1995). Cell, 81, 857-866.
Romana SP, Mauchauffe M, Le Coniat M, Chumakov I, Le Paslier D, Berger R and Bernard OA. (1995a). Blood, 85, 3662-3670.
Romana SP, Poirel H, Le Coniat M, Flexor M-A, Mauchauffé M, Jonveaux P, Macintyre EA, Berger R and Bernard OA. (1995b). Blood, 86, 4263-4269.
Rosenfeld C, Goutner A, Choquet C, Venuat A-M, Kayibanda B, Pico J-L and Greaves MF. (1977). Nature. 267, 841-843.
Sambrook J, Fritsch EF and Maniatis T. (1989). Molecular cloning: A Laboratory Manual. Second Edition. Cold Spring Harbor Laboratory Press.
Sato Y, Suto Y, Pietenpol J, Golub TR, Gilliland DG, Davis EM, Le Beau MM, Roberts JM, Vogelstein B, Rowley JD and Bohlander SK. (1995). Blood, 86, 1525-1533.
Seth A and Papas TS. (1990). Oncogene, 5, 1761-1767.
Shurtleff SA, Buijs A, Behm FG, Rubnitz JE, Raimondi SC, Hancock ML, Chan GC-H, Pui C-H, Grosveld G and Downing JR. (1995). Leukemia, 9, 1985-1989.
Sorensen PHB, Lessnick SL, Lopez-Terrada D, Liu XF, Triche TJ and Denny CT. (1994). Nature Genet., 6, 146-151.
Stegmaier K, Pendse S, Barker FG, Bray-Ward P, Ward DC, Montgomery KT, Krauter KS, Reynolds C, Sklar J, Donnelly M, Bohlander SK, Rowley JD, Sallan SE, Gilliland DG and Golub TR. (1995). Blood, 86, 38-44.
Venaut A-M, Testu M-J and Rosenfeld C. (1981). Cancer Genet. Cytogenet., 3, 327-334.
Wasylyk B, Hahn SL and Giovane A. (1993). Eur. J. Biochem., 211, 7-18.
Yang BS, Houser CA, Henkel G, Colman MS, Van Beveren C, Stacey KJ, Hume DA, Maki RA and Ostrowski MC. (1996). Mol. Cell. Biol., 16, 538-547.
Zucman J, Melot T, Desmaze C, Ghysdael J, Plougastel B, Peter M, Zucker J, Triche T, Sheer D, Turc-Carel C, Ambros P, Combaret V, Lenoir G, Thomas G and Delattre O. (1993). EMBO J., 12, 4481-4487.