Article (Scientific journals)
RZooRoH: An R package to characterize individual genomic autozygosity and identify homozygous-by-descent segments
Bertrand, Amandine; Kadri, N. K.; Flori, L. et al.
2019In Methods in Ecology and Evolution, 10 (6), p. 860-866
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Abstract :
[en] Identifying homozygous-by-descent (HBD) regions in individual genomes is highly valuable to infer the recent history of populations and to provide insights into trait architecture. Here, we present the RZooRoH R-package that implements an efficient and accurate model-based approach to identify HBD segments. The underlying hidden Markov model partitions the genome-wide individual autozygosity into different age-related HBD classes while accounting for genotyping errors and genetic map information. The RZooRoH package is user-friendly and versatile, accepting either genotyping or sequencing (including low-coverage) data in various formats. Through numerical maximization and parallelization, computational performances were improved compared to our initial Fortran implementation of the model. The package allows to evaluate and compare various models defined by their number of HBD classes and it also provides several graphical functions that help interpretation of the results. RZooRoH is an efficient tool that proves particularly suited for sub-optimal datasets (e.g. low marker density, individual low-coverage sequencing, uneven marker spacing) and for individuals from populations with complex demographic histories. RZooRoH is available from CRAN: https://CRAN.R-project.org/package=RZooRoH. © 2019 The Authors. Methods in Ecology and Evolution © 2019 British Ecological Society
Disciplines :
Environmental sciences & ecology
Veterinary medicine & animal health
Animal production & animal husbandry
Agriculture & agronomy
Genetics & genetic processes
Zoology
Author, co-author :
Bertrand, Amandine ;  Université de Liège - ULiège > Département des sciences de la vie > Génomique fonctionnelle et imagerie moléculaire végétale
Kadri, N. K.;  Unit of Animal Genomics, GIGA-R & Faculty of Veterinary Medicine, University of Liège, Liège, Belgium
Flori, L.;  SELMET, INRA, CIRAD, Montpellier Supagro, University of Montpellier, Montpellier, France
Gautier, M.;  INRA, UMR CBGP (INRA – IRD – Cirad – Montpellier SupAgro), Montferrier-sur-Lez, France
Druet, Tom  ;  Université de Liège - ULiège > Medical Genomics-Unit of Animal Genomics
Language :
English
Title :
RZooRoH: An R package to characterize individual genomic autozygosity and identify homozygous-by-descent segments
Publication date :
2019
Journal title :
Methods in Ecology and Evolution
eISSN :
2041-210X
Publisher :
British Ecological Society
Volume :
10
Issue :
6
Pages :
860-866
Peer reviewed :
Peer Reviewed verified by ORBi
Tags :
CÉCI : Consortium des Équipements de Calcul Intensif
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique
Available on ORBi :
since 11 April 2019

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