Article (Scientific journals)
Does an integrated boost increase acute toxicity in prone hypofractionated breast irradiation? A randomized controlled trial
Paelinck, L.; GULYBAN, Akos; Lakosi, F. et al.
2017In Radiotherapy and Oncology, 122 (1), p. 30-36
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Keywords :
Breast cancer; Hypofractionation; Prone; Simultaneous integrated boost; Whole-breast irradiation; Article; Breast Neoplasms; Aged; Breast; Dose Hypofractionation; Female; Humans; Middle Aged; Prone Position; Radiotherapy Dosage
Abstract :
[en] Background and purpose The safety of a simultaneous integrated boost (SIB) in combination with prone hypofractionated whole-breast irradiation (WBI) was investigated. Materials and methods 167 patients were randomized between WBI with a sequential boost (SeB) or SIB. All patients were treated in prone position to 40.05 Gy in 15 fractions to the whole breast. In the control arm, a SeB of 10 Gy in 4 fractions (negative surgical margins) or 14.88 Gy in 6 fractions (transsection) was prescribed. In the experimental arm a SIB of 46.8 or 49.95 Gy (negative and positive surgical margins, respectively) was prescribed. Results Patient age was the only significantly different parameter between treatment arms with patients in the SIB arm being slightly older. In both arms, 6/83 patients developed moist desquamation. Grade 2/3 dermatitis was significantly more frequent in the SeB arm (38/83 vs 24/83 patients, p = 0.037). In the SIB and SeB arm, respectively, 36 patients (43%) and 51 patients (61%) developed pruritus (p = 0.015). The incidence of oedema was lower in the SIB arm (59 vs 68 patients), but not statistically significant (p = 0.071). Conclusions The primary endpoint, moist desquamation, was not significantly different between treatment arms. © 2016 Elsevier Ireland Ltd
Disciplines :
Oncology
Author, co-author :
Paelinck, L.;  Dept. of Radiation Oncology, Ghent University Hospital, Belgium
GULYBAN, Akos ;  Dept. of Radiation Oncology, Liège University Hospital, Belgium
Lakosi, F.;  Dept. of Radiation Oncology, Liège University Hospital, Belgium
Vercauteren, T.;  Dept. of Radiation Oncology, Ghent University Hospital, Belgium
De Gersem, W.;  Dept. of Radiation Oncology, Ghent University Hospital, Belgium, Dept. of Radiotherapy and Experimental Cancer Research, Ghent University, Belgium
Speleers, B.;  Dept. of Radiotherapy and Experimental Cancer Research, Ghent University, Belgium
Monten, C.;  Dept. of Radiation Oncology, Ghent University Hospital, Belgium, Dept. of Radiotherapy and Experimental Cancer Research, Ghent University, Belgium
Mulliez, T.;  Dept. of Radiation Oncology, Ghent University Hospital, Belgium
Berkovic, P.;  Dept. of Radiation Oncology, Liège University Hospital, Belgium
van Greveling, A.;  Dept. of Radiation Oncology, Ghent University Hospital, Belgium
Decoster, F.;  Dept. of Radiation Oncology, Ghent University Hospital, Belgium
Coucke, Philippe  ;  Université de Liège - ULiège > Département des sciences cliniques > Radiothérapie
De Neve, W.;  Dept. of Radiation Oncology, Ghent University Hospital, Belgium, Dept. of Radiotherapy and Experimental Cancer Research, Ghent University, Belgium
Veldeman, L.;  Dept. of Radiation Oncology, Ghent University Hospital, Belgium, Dept. of Radiotherapy and Experimental Cancer Research, Ghent University, Belgium
More authors (4 more) Less
Language :
English
Title :
Does an integrated boost increase acute toxicity in prone hypofractionated breast irradiation? A randomized controlled trial
Publication date :
2017
Journal title :
Radiotherapy and Oncology
ISSN :
0167-8140
eISSN :
1879-0887
Publisher :
Elsevier Ireland Ltd
Volume :
122
Issue :
1
Pages :
30-36
Peer reviewed :
Peer Reviewed verified by ORBi
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