P2X1-mediated ERK2 activation amplifies the collagen-induced platelet secretion by enhancing myosin light chain kinase activation.

Oury, Cécile; Toth-Zsamboki, Emese; Cornelissen, Heidi; De Vos, Rita; Vermylen, Jos; Hoylaerts, Marc F

doi:10.1074/jbc.M308452200

Article (Scientific journals)

P2X1-mediated ERK2 activation amplifies the collagen-induced platelet secretion by enhancing myosin light chain kinase activation.

Oury, Cécile; Toth-Zsamboki, Emese; Cornelissen, Heidi et al.

2003 • In Journal of Biological Chemistry

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/23391

DOI
10.1074/jbc.M308452200

PubMed
14500714

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Keywords :

platelet degranulation; signaling; purinergic receptors

Abstract :

[en] This study shows that, at low doses of collagen, glycoprotein VI activation leads to early protein kinase C- and MLC kinase-dependent platelet degranulation. Rapidly released ATP triggers P2X1 -mediated Ca2+ influx, activating ERK2, in turn amplifying platelet secretion by reinforcing the early MLC kinase phosphorylation. Hence, the P2X1-ERK2-MLC axis contributes to collagen-induced platelet activation by enhancing platelet degranulation.

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Oury, Cécile ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > GIGA-R : Génétique humaine

Toth-Zsamboki, Emese; Katholieke Universiteit Leuven - KUL > Molecular and Cellular Medicine > CMVB

Cornelissen, Heidi; Katholieke Universiteit Leuven - KUL > Molecular and Cellular Medicine > CMVB

De Vos, Rita; Katholieke Universiteit Leuven - KUL > Molecular and Cellular Medicine > Morphology and Molecular Pathology

Vermylen, Jos; Katholieke Universiteit Leuven - KUL > Molecular and Cellular Medicine > CMVB

Hoylaerts, Marc F; Katholieke Universiteit Leuven - KUL > Molecular and Cellular Medicine > CMVB

Language :

English

Title :

P2X1-mediated ERK2 activation amplifies the collagen-induced platelet secretion by enhancing myosin light chain kinase activation.

Publication date :

2003

Journal title :

Journal of Biological Chemistry

ISSN :

0021-9258

eISSN :

1083-351X

Publisher :

American Society for Biochemistry and Molecular Biology, Baltimore, United States - Maryland

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 23 September 2009

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