Reference : P2X1-mediated ERK2 activation amplifies the collagen-induced platelet secretion by en...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/23391
P2X1-mediated ERK2 activation amplifies the collagen-induced platelet secretion by enhancing myosin light chain kinase activation.
English
Oury, Cécile mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > GIGA-R : Génétique humaine >]
Toth-Zsamboki, Emese [Katholieke Universiteit Leuven - KUL > Molecular and Cellular Medicine > CMVB > >]
Cornelissen, Heidi [Katholieke Universiteit Leuven - KUL > Molecular and Cellular Medicine > CMVB > >]
De Vos, Rita [Katholieke Universiteit Leuven - KUL > Molecular and Cellular Medicine > Morphology and Molecular Pathology > >]
Vermylen, Jos [Katholieke Universiteit Leuven - KUL > Molecular and Cellular Medicine > CMVB > >]
Hoylaerts, Marc F [Katholieke Universiteit Leuven - KUL > Molecular and Cellular Medicine > CMVB > >]
2003
Journal of Biological Chemistry
American Society for Biochemistry and Molecular Biology
Yes (verified by ORBi)
International
0021-9258
1083-351X
Baltimore
MD
[en] platelet degranulation ; signaling ; purinergic receptors
[en] This study shows that, at low doses of collagen, glycoprotein VI activation leads to early protein kinase C- and MLC kinase-dependent platelet degranulation. Rapidly released ATP triggers P2X1 -mediated Ca2+ influx, activating ERK2, in turn amplifying platelet secretion by reinforcing the early MLC kinase phosphorylation. Hence, the P2X1-ERK2-MLC axis contributes to collagen-induced platelet activation by enhancing platelet degranulation.
http://hdl.handle.net/2268/23391
10.1074/jbc.M308452200

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