Article (Scientific journals)
Validation of standardized creatinine and cystatin C GFR estimating equations in a large multicentre European cohort of children
Björk, J.; Nyman, U.; Berg, U. et al.
2019In Pediatric Nephrology, 34 (6), p. 1087-1098
Peer Reviewed verified by ORBi
 

Files


Full Text
BjorkPediatrNephrol2019.pdf
Author postprint (661.39 kB)
Download

We Thank Springer


All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Children; Chronic kidney disease; Glomerular filtration rate; Kidney function tests; Renal failure
Abstract :
[en] Background: Most validations of paediatric glomerular filtration rate (GFR) estimating equations using standardized creatinine (CR) and cystatin C (CYS) assays have comprised relatively small cohorts, which makes accuracy across subgroups of GFR, age, body mass index (BMI) and gender uncertain. To overcome this, a large cohort of children referred for GFR determination has been established from several European medical centres. Methods: Three thousand four hundred eight measurements of GFR (mGFR) using plasma clearance of exogenous substances were performed in 2218 children aged 2–17 years. Validated equations included Schwartz-2009CR/2012CR/CYS/CR+CYS, FASCR/CYS/CR+CYS, LMRCR, Schwartz-LyonCR, BergCYS, CAPACYS, CKD-EPICYS, AndersenCR+CYS and arithmetic means of the best single-marker equations in explorative analysis. Five metrics were used to compare the performance of the GFR equations: bias, precision and three accuracy measures including the percentage of GFR estimates (eGFR) within ± 10% (P10) and ± 30% (P30) of mGFR. Results: Three of the cystatin C equations, BergCYS, CAPACYS and CKD-EPICYS, exhibited low bias and generally satisfactory accuracy across all levels of mGFR; CKD-EPICYS had more stable performance across gender than the two other equations. Among creatinine equations, Schwartz-LyonCR had the best performance but was inaccurate at mGFR < 30 mL/min/1.73 m2 and in underweight patients. Arithmetic means of the best creatinine and cystatin C equations above improved bias compared to the existing composite creatinine+cystatin C equations. Conclusions: The present study strongly suggests that cystatin C should be the primary biomarker of choice when estimating GFR in children with decreased GFR. Arithmetic means of well-performing single-marker equations improve accuracy further at most mGFR levels and have practical advantages compared to composite equations. © 2019, IPNA.
Disciplines :
Laboratory medicine & medical technology
Urology & nephrology
Author, co-author :
Björk, J.;  Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden, Clinical Studies Sweden, Forum South, Skåne University Hospital, Lund, Sweden
Nyman, U.;  Department of Translational Medicine, Division of Medical Radiology, Lund University, Malmö, Sweden
Berg, U.;  Department of Clinical Science, Intervention and Technology, Division of Paediatrics, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
Delanaye, Pierre  ;  Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
Dubourg, L.;  Néphrologie, Dialyse, Hypertension et Exploration Fonctionnelle Rénale, Groupement Hospitalier Edouard Herriot, Hospices Civils de Lyon, Université Claude Bernard Lyon 1, and Laboratory of Tissue Biology and Therapeutic Engineering, UMR 5305 CNRS, Université Claude Bernard Lyon 1, Lyon, France
Goffin, K.;  Department of Nuclear Medicine & Molecular Imaging, University Hospital Leuven, Leuven, Belgium
Grubb, A.;  Department of Clinical Chemistry, Skåne University Hospital, Lund, Lund University, Lund, Sweden
Hansson, M.;  Department of Laboratory Medicine, Division of Clinical Chemistry, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
Littmann, K.;  Department of Laboratory Medicine, Division of Clinical Chemistry, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
Åsling-Monemi, K.;  Department of Clinical Science, Intervention and Technology, Division of Paediatrics, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
Bökenkamp, A.;  Emma Children’s Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands
Pottel, H.;  Department of Public Health and Primary Care, KU Leuven Campus Kulak Kortrijk, Kortrijk, Belgium
Language :
English
Title :
Validation of standardized creatinine and cystatin C GFR estimating equations in a large multicentre European cohort of children
Publication date :
2019
Journal title :
Pediatric Nephrology
ISSN :
0931-041X
eISSN :
1432-198X
Publisher :
Springer Verlag
Volume :
34
Issue :
6
Pages :
1087-1098
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 11 March 2019

Statistics


Number of views
312 (4 by ULiège)
Number of downloads
457 (0 by ULiège)

Scopus citations®
 
46
Scopus citations®
without self-citations
34
OpenCitations
 
41

Bibliography


Similar publications



Contact ORBi