A case of giant cell arteritis associated with culture-proven Coxiella burnetii aortitis

Aortitis; Coxiella burnetii; Giant cell arteritis; Q fever; Vascular infection; Article; IS1111 gene; IS30a gene; Aged; Anti-Bacterial Agents; Aorta, Abdominal; Doxycycline; Fluorodeoxyglucose F18; Heart Valve Prosthesis Implantation; Humans; Hydroxychloroquine; Male; Positron Emission Tomography Computed Tomography; Treatment Outcome

Abstract :

[en] A case of proven Coxiella burnetii aortitis, possibly associated with giant cell arteritis (GCA), is reported. A 72-year-old man, who is a hunter, presented with weight loss, fever, jaw claudication, and hardened temporal arteries associated with a persistent inflammatory syndrome and arteritis of the whole aorta, including the brachiocephalic arteries, as seen on 18F-fluorodeoxyglucose positron emission tomography/computed tomography. The diagnosis of GCA was retained, and treatment with prednisolone was started. Given the aneurysm of the abdominal aorta, the patient underwent replacement of the abdominal aorta with an allograft. Histology showed intense chronic arteritis attributed to atherosclerosis with dissection. However, Coxiella burnetii infection was confirmed by serology and then by culture and molecular biology on the surgical specimen. A combination of hydroxychloroquine and doxycycline was added to tapered prednisolone and the outcome was favourable. © 2018 The Author(s)

Disciplines :

Immunology & infectious disease

Author, co-author :

de Worm, S.; Internal General Medicine and Infectious Diseases, CHU de Liège, Liège, 4000, Belgium

GIOT, Jean-Baptiste ; Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service des maladies infectieuses - médecine interne

Courtoy, C.; Rheumatology, CHR de Verviers, Verviers, 4800, Belgium

Gillet, E.; General Practitioner, Battice, 4651, Belgium

Amrane, S.; Aix Marseille Université, IRD, APHM, MEPHI, IHU-Méditerranée Infection, Marseille, France

Huynen, Pascale ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques

Van Esbroeck, M.; Belgian National Reference Centre for Coxiella burnetii, Institute of Tropical Medicine, Anvers, 2000, Belgium

Prudent, E.; Aix Marseille Université, IRD, APHM, MEPHI, IHU-Méditerranée Infection, Marseille, France

Lepidi, H.; Aix Marseille Université, IRD, APHM, MEPHI, IHU-Méditerranée Infection, Marseille, France

Million, M.; Aix Marseille Université, IRD, APHM, MEPHI, IHU-Méditerranée Infection, Marseille, France

Moutschen, Michel ; Université de Liège - ULiège > Département des sciences cliniques > Immunopath. - Maladies infect. et médec. interne gén.

Raoult, D.; Aix Marseille Université, IRD, APHM, MEPHI, IHU-Méditerranée Infection, Marseille, France

Language :

English

Title :

A case of giant cell arteritis associated with culture-proven Coxiella burnetii aortitis

Publication date :

2018

Journal title :

International Journal of Infectious Diseases

ISSN :

1201-9712

eISSN :

1878-3511

Publisher :

Elsevier B.V.

Volume :

Pages :

50-54

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 26 February 2019

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