Large ovarian endometriomas.

Combined Modality Therapy; Endometriosis/drug therapy/pathology/surgery; Female; Gonadotropin-Releasing Hormone/agonists; Goserelin/therapeutic use; Humans; Infertility, Female/drug therapy/etiology/surgery; Laser Therapy; Metaplasia; Ovarian Cysts/drug therapy/pathology/surgery; Ovarian Diseases/drug therapy/pathology/surgery; Pregnancy; Recurrence

Abstract :

[en] The management of large endometriomas was described in a series of 814 patients. Combined therapy using gonadotrophin-releasing hormone agonist (GnRHa) and carbon dioxide laser laparoscopy was proposed. Drainage and GnRHa for 12 weeks provoked a reduction of the endometrioma size up to 50% of the initial value. After vaporization of the internal wall, a cumulative pregnancy of 51% after 1 year was achieved. A recurrence rate of 8% was observed for a follow-up of 2-11 years. Histological data demonstrated that the epithelium covering the ovary which is the mesothelium can invaginate in the ovarian cortex. Some of the invaginations were seen to be continuous with endometrial tissue, strongly suggesting the metaplasia theory in the pathogenesis of ovarian endometrioma.

Disciplines :

Reproductive medicine (gynecology, andrology, obstetrics)

Author, co-author :

Donnez, J.

Nisolle, Michelle ; Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique

Gillet, N.

Smets, M.

Bassil, S.

Casanas-Roux, F.

Language :

English

Title :

Large ovarian endometriomas.

Publication date :

1996

Journal title :

Human Reproduction

ISSN :

0268-1161

eISSN :

1460-2350

Publisher :

Oxford University Press, Oxford, United Kingdom

Volume :

Issue :

Pages :

641-6

Available on ORBi :

since 20 February 2019

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Scopus citations^®

328

Scopus citations^®
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288

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279

Bibliography

American Fertility Society (1985) Revised American Fertility Society classification of endometriosis. Fertil. Steril., 58, 351-362.
Brosens, I., Puttemans, P. and Deprest, J (1994) The endoscopic localization of endometrial implants in the ovarian chocolate cyst. Fertil. Steril., 61, 1034-1038.
Brosens, I (1995a) Ovarian endometriosis. In Shaw, R. (ed.), Endometriosis. Parthenon Publishing, London, Camforth, p. 97.
Brosens, I. (1995b) Endoscopic exploration and classification of the chocolate cyst. Hum. Reprod., 9, 2213-2214.
Brosens, I., Donnez, J. and Benagiano, G (1993) Improving the classification of endometriosis. Hum. Reprod., 8, 1792-1795.
Buttram, V., Reiter, R. and Ward, S. (1985) Treatment of endometriosis with danazol: report of a 6-year prospective study. Fertil. Steril., 43, 353.
Canis, M., Mage, G., Wattiez, A. et al. (1992a) Second look laparoscopy after laparoscopic cystectomy of large endometriomas. Fertil. Steril., 58, 617-619.
Canis, M., Pouly, J.L. and Wattiez, A. (1992b) Incidence of bilateral adnexal disease in severe endometriosis (revised American Fertility Society (AFS), stage IV): should a stage V be included in the AFS classification. Fertil. Steril., 57, 601-602.
Canis, M., Wattiez, A., Pouly, J.L. et al. (1993) Laparoscopic treatment of endometriosis. In Brosens, I. and Donnez, J. (eds), The Current Status of Endometriosis. Research and Management. Parthenon Publishing, Carnforth, UK, pp. 407-417.
Czernobilsky, O. and Morris, W.J. (1979) A histologic study of ovarian endometriosis with emphasis on hyperplastic and atypical changes. Obstet. Gynecol. 53, 318-323.
Donnez, J. (1987) CO2 laser laparoscopy in infertile women with adhesions or endometriosis. Fertil. Steril., 48, 390-394.
Donnez, J. (1993) Rationale for surgery. In Brosens, I. and Donnez, J. (eds), Current Status of Endometriosis. Research and Management, Vol. I. Parthenon Publishing, Carnforth, UK, pp. 385-395.
Donnez, J. and Nisolle, M. (1991) Laparoscopic management of large ovarian endometrial cyst: use of fibrin sealant. J. Gyn. Surg., 7, 163-167.
Donnez, J , Nisolle, M and Casanas-Roux, F. (1989a) Administration of nasal buserelin as compared with subcutaneous buserelin implant for endometriosis. Fertil., Steril., 52, 27-30.
Donnez, J., Nisolle, M. and Casanas-Roux, F. (1989b) CO2 laser laparoscopy in infertile women with adnexal adhesions and women with tubal occlusion. J. Gyn. Surg., 5, 47-53.
Donnez, J., Nisolle, M. and Casanas-Roux, F. (1990) Endometriosis-associated infertility: evaluation of preoperative use of danazol, gestrinone and buserelin. Int J. Fertil., 42, 128.
Donnez, J., Nisolle, M. and Casanas-Roux, F. (1992) Three-dimensional architectures of peritoneal endometriosis. Fertil. Steril., 57, 980-983.
Donnez, J., Nisolle, M., Gillerot, S. et al. (1994) Ovarian endometrial cyst: the role of gonadotropin-releasing hormone agonist and/or drainage. Fertil. Steril. 62, 63-66.
Donnez. J., Nisolle, M., Casanas-Roux, F. et al. (1995) Rectovaginal septum, endometriosis or adenomyosis: laparoscopic management in a series of 231 patients. Hum. Reprod , 10, 630-635.
Duhuisson, J.B. and Chapron, C. (1994) Classification of endometriosis. The need for modification. Hum. Reprod., 9, 2214-2215.
Payez, J.A and Vogel, M.S. (1991) Comparison of different treatment methods of endometriosis by laparoscopy. Obstet. Gynecol., 78, 660-665
Gabe, M. (1968) Les colorations topographiques. In Masson and Co (eds). Techniques Histologiques, Paris, pp. 203-256.
Gordts, S., Boeckx, W. and Brosens, I. (1994) Microsurgery of endometriosis in infertile patients. Fertil. Steril., 42, 520-525.
Hughesdon, P.E. (1957) The structure of endometrial cysts of the ovary J. Obstet. Gynaecol. Nr. Emp., 44, 481-487.
Motta, P.M., Van Blerkom, J. and Makabe, S. (1980) Changes to the surface morphology of ovarian germinal epithelium during the reproductive life and in some pathological conditions. J. Sub. Cytol., 12, 407-425.
Nezhat, F , Nezhat, C., Allan, C.J. et al. (1992) A clinical and histologic classification of endometriomas: implications for a mechanism of pathogenesis. J. Reprod. Med., 37, 771-776.
Nezhat, F., Nezhat, C., Nezhat, C. and Admon, D. (1994) A fresh look at ovarian endometriomas. Contemporary Ob/Gyn., 81-94.
Nezhat, C., Nezhat, F., Nezhat, C. and Siedman, D. (1994) Classification of endometriosis. Improving the classification of endometriotic ovarian cysts. Hum. Reprod., 9, 2212-2213.
Nisolle, M., Casanas-Roux, F. and Donnez, J. (1988) Histologic study of ovarian endometriosis after hormonal therapy. Fertil. Steril., 49, 423-426
Nisolle, M., Casanas-Roux, F., Wyns, Ch. et al. (1994) Immunohistochemical analysis of estrogen and progesterone receptors in endometrium and peritoneal endometriosis: a new quantitative method. Fertil. Steril., 62, 751-759.
Nisolle, M., Casanas-Roux, F. and Donnez, J. (1995) Coexpression of cytokeratin and vimentin in eutopic endometrium and endometriosis throughout the menstrual cycle: evaluation by a computerized method Fertil. Steril., 64, 69-75.
Sampson, J. A. (1921) Perforating haemorrhagic (chocolate) cysts of the ovary. Arch. Surg., 3, 245-323.
Sampson, J.A. (1927) Peritoneal endometriosis due to the menstrual dissemination of endometrial tissue into the peritoneal cavity. Am. J. Obstet Gynecol., 14, 422-469.
Shaw, R.W. (1992) The role of GnRH analogues in the treatment of endometriosis. Br. J. Obstet. Gynaecol. 99, 9-12.