Reference : A critical role for dendritic cells in the evolution of IL-1beta-mediated murine airw...
Scientific journals : Article
Life sciences : Multidisciplinary, general & others
A critical role for dendritic cells in the evolution of IL-1beta-mediated murine airway disease.
Hashimoto, Mitsuo [> >]
Yanagisawa, Haruhiko [> >]
Minagawa, Shunsuke [> >]
Sen, Debasish [> >]
Goodsell, Amanda [> >]
Ma, Royce [> >]
Moermans, Catherine mailto [Université de Liège - ULiège > > >]
McKnelly, Kate J. [> >]
Baron, Jody L. [> >]
Krummel, Matthew F. [> >]
Nishimura, Stephen L. [> >]
Journal of Immunology
Yes (verified by ORBi)
United States
[en] Adaptive Immunity ; Animals ; Dendritic Cells/immunology/pathology ; Interleukin-1beta/genetics/immunology ; Mice ; Mice, Knockout ; Pulmonary Disease, Chronic Obstructive/genetics/immunology/pathology ; Pulmonary Fibrosis/genetics/immunology ; Receptors, Antigen, T-Cell, alpha-beta/genetics/immunology ; T-Lymphocytes/immunology/pathology
[en] Chronic airway inflammation and fibrosis, known as airway remodeling, are defining features of chronic obstructive pulmonary disease and are refractory to current treatments. How and whether chronic inflammation contributes to airway fibrosis remain controversial. In this study, we use a model of chronic obstructive pulmonary disease airway disease utilizing adenoviral delivery of IL-1beta to determine that adaptive T cell immunity is required for airway remodeling because mice deficient in alpha/beta T cells (tcra(-/-)) are protected. Dendritic cells (DCs) accumulate around chronic obstructive pulmonary disease airways and are critical to prime adaptive immunity, but they have not been shown to directly influence airway remodeling. We show that DC depletion or deficiency in the crucial DC chemokine receptor ccr6 both protect from adenoviral IL-1beta-induced airway adaptive T cell immune responses and fibrosis in mice. These results provide evidence that chronic airway inflammation, mediated by accumulation of alpha/beta T cells and driven by DCs, is critical to airway fibrosis.
Copyright (c) 2015 by The American Association of Immunologists, Inc.

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