Stability of 90 mg/mL cefuroxime sodium solution for administration by continuous infusion.

[en] Continuous infusions of beta-lactam antibiotics increase pharmacokinetic/pharmacodynamic target attainment. However, this way of administration brings about some practical issues such as stability. This study aims to determine the stability of a 90 mg/mL cefuroxime sodium solution. Cefuroxime sodium was reconstituted and mixed with 50-mL 0.9% saline to produce 90 mg/mL solution in polypropylene syringes which were stored at 4 degrees C, 25 degrees C and 40 degrees C. Cefuroxime sodium concentration was determined periodically over 14 days using a stability-indicating high-performance liquid chromatographic method with ultra-violet detection. The loss in concentration was less than 10% after 2 days of storage at 25 degrees C and less than 5% after 14 days of storage at 4 degrees C. The concentration fell below 60% after 1 day at 40 degrees C. Solutions darken in appearance with time and heat. A 90 mg/mL cefuroxime sodium solution stored in polypropylene syringes is stable for 2 days at 25 degrees C and for at least 14 days at 4 degrees C.

Research Center/Unit :

CIRM - Centre Interdisciplinaire de Recherche sur le Médicament - ULiège

Disciplines :

Pharmacy, pharmacology & toxicology

Author, co-author :

Vercheval, Christelle ; Centre Hospitalier Universitaire de Liège - CHU > Direction médicale > Service de pharmacie clinique

STREEL, Sophie ; Centre Hospitalier Universitaire de Liège - CHU > Département de pharmacie hospitalière > Département de pharmacie hospitalière

Servais, Anne-Catherine ; Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments

Fillet, Marianne ; Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments

Van Hees, Thierry ; Université de Liège - ULiège > Département de pharmacie > Pharmacie clinique et pharmacie hospitalière

Language :

English

Title :

Stability of 90 mg/mL cefuroxime sodium solution for administration by continuous infusion.

Publication date :

2018

Journal title :

Journal of Chemotherapy

ISSN :

1120-009X

eISSN :

1973-9478

Publisher :

Taylor and Francis, United Kingdom

Volume :

Issue :

6-8

Pages :

371-374

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 05 February 2019

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