Stability of 90 mg/mL cefuroxime sodium solution for administration by continuous infusion.

Continuous infusions of beta-lactam antibiotics increase pharmacokinetic/pharmacodynamic target attainment. However, this way of administration brings about some practical issues such as stability. This study aims to determine the stability of a 90 mg/mL cefuroxime sodium solution. Cefuroxime sodium was reconstituted and mixed with 50-mL 0.9% saline to produce 90 mg/mL solution in polypropylene syringes which were stored at 4 degrees C, 25 degrees C and 40 degrees C. Cefuroxime sodium concentration was determined periodically over 14 days using a stability-indicating high-performance liquid chromatographic method with ultra-violet detection. The loss in concentration was less than 10% after 2 days of storage at 25 degrees C and less than 5% after 14 days of storage at 4 degrees C. The concentration fell below 60% after 1 day at 40 degrees C. Solutions darken in appearance with time and heat. A 90 mg/mL cefuroxime sodium solution stored in polypropylene syringes is stable for 2 days at 25 degrees C and for at least 14 days at 4 degrees C.