Reference : Prosapip1-Dependent Synaptic Adaptations in the Nucleus Accumbens Drive Alcohol Intak...
Scientific journals : Article
Human health sciences : Neurology
http://hdl.handle.net/2268/232503
Prosapip1-Dependent Synaptic Adaptations in the Nucleus Accumbens Drive Alcohol Intake, Seeking, and Reward
English
Laguesse, Sophie mailto [Université de Liège - ULiège > > Giga - Neurosciences >]
Morisot, N. [Department of Neurology, University of California, San Francisco, CA, United States, N.M. Brains On-line LLC, South San Francisco, CA, United States]
Shin, J. H. [Laboratory on Neurobiology of Compulsive Behaviors, National Institute of Alcohol Abuse and Alcoholism, US National Institutes of Health, Bethesda, MD, United States]
Liu, F. [Department of Neurology, University of California, San Francisco, CA, United States, School of Life Sciences, Sun Yat-sen University, Guangzhou, China]
Adrover, M. F. [Laboratory on Neurobiology of Compulsive Behaviors, National Institute of Alcohol Abuse and Alcoholism, US National Institutes of Health, Bethesda, MD, United States]
Sakhai, S. A. [Department of Neurology, University of California, San Francisco, CA, United States]
Lopez, M. []
Phamluong, K. [Department of Neurology, University of California, San Francisco, CA, United States]
Griffin, W. C. [III, Charleston Alcohol Research Center, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, United States]
Becker, H. C. [Charleston Alcohol Research Center, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, United States, Department of Neurosciences, Medical University of South Carolina, Charleston, SC, United States, RHJ Department of Veterans Affairs Medical Center, Charleston, SC, United States]
Bender, K. J. [Department of Neurology, University of California, San Francisco, CA, United States]
Alvarez, V. A. [Laboratory on Neurobiology of Compulsive Behaviors, National Institute of Alcohol Abuse and Alcoholism, US National Institutes of Health, Bethesda, MD, United States]
Ron, D. [Department of Neurology, University of California, San Francisco, CA, United States]
Sep-2017
Neuron
Cell Press
96
1
145-159.e8
Yes (verified by ORBi)
International
0896-6273
1097-4199
[en] Actin ; Addiction ; Alcohol ; Dendritic spines ; Plasticity ; Prosapip1 ; AMPA receptor ; GluA2 protein ; Prosapip1 protein ; AMPA receptor ; ProSAPiP1 protein, mouse ; Article ; RNA sequence ; RNA translation ; Actin Cytoskeleton ; Alcohol Drinking ; Animals ; Carrier Proteins ; Dendritic Spines ; Drug-Seeking Behavior ; Ethanol ; Male ; Membrane Proteins ; Mice ; Multiprotein Complexes ; Neuronal Plasticity ; Nucleus Accumbens ; Receptors, AMPA ; Reward ; Self Administration ; TOR Serine-Threonine Kinases
[en] The mammalian target of rapamycin complex 1 (mTORC1), a transducer of local dendritic translation, participates in learning and memory processes as well as in mechanisms underlying alcohol-drinking behaviors. Using an unbiased RNA-seq approach, we identified Prosapip1 as a novel downstream target of mTORC1 whose translation and consequent synaptic protein expression are increased in the nucleus accumbens (NAc) of mice excessively consuming alcohol. We demonstrate that alcohol-dependent increases in Prosapip1 levels promote the formation of actin filaments, leading to changes in dendritic spine morphology of NAc medium spiny neurons (MSNs). We further demonstrate that Prosapip1 is required for alcohol-dependent synaptic localization of GluA2 lacking AMPA receptors in NAc shell MSNs. Finally, we present data implicating Prosapip1 in mechanisms underlying alcohol self-administration and reward. Together, these data suggest that Prosapip1 in the NAc is a molecular transducer of structural and synaptic alterations that drive and/or maintain excessive alcohol use. Laguesse et al. identified Prosapip1 as a novel downstream target of mTORC1 in the nucleus accumbens that promotes actin reorganization as well as morphological and synaptic alterations that in turn drive alcohol drinking and seeking behaviors. © 2017 Elsevier Inc.
http://hdl.handle.net/2268/232503
10.1016/j.neuron.2017.08.037

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Open access
Prosapip1 paper.pdfPublisher postprint4.34 MBView/Open

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.